Results 121 to 130 of about 492 (137)

Toosendanin induces apoptosis through suppression of JNK signaling pathway in HL-60 cells

Toxicology in Vitro, 2013
Toosendanin (TSN), a triterpenoid isolated from Melia toosendan Sieb. et Zucc., has been found to suppress proliferation and induce apoptosis in a variety of human cancer cells. However, the mechanism how TSN induces apoptosis remains poorly understood.
Jianming, Ju, Zhichao, Qi, Xueting, Cai, Peng, Cao, Nan, Liu, Shuzhen, Wang, Yijun, Chen   +6 more
openaire   +2 more sources

Integrated Proteomics, Biological Functional Assessments, and Metabolomics Reveal Toosendanin-Induced Hepatic Energy Metabolic Disorders

Chemical Research in Toxicology, 2019
Toosendanin (TSN), a compound from Melia toosendan, exhibits severe hepatotoxicity, which restricts its clinical application. However, the mechanism is not clear. Our previous research found that covalent modification of TSN for proteins might be a possible reason using human liver microsomes, and the glycolytic enzymes, triosephosphate isomerase 1 ...
Xiaojing Yan, Yue Zhuo, Xiqing Bian, Jianmin Li, Yida Zhang, Lidong Ma, Guanghua Lu, Ming-Quan Guo, Jian-Lin Wu, Na Li   +9 more
openaire   +2 more sources

Nanoporous 3D Polyurethane for Toosendanin Adsorption, Encapsulation, and High-Efficient Utilization

Journal of Agricultural and Food Chemistry
Nanoporous 3D-polyurethane (3D-PU) was prepared based on nano-CaCO3 templated controllably confined polymerization assembly and weak acid etching strategies. Nanopores with diameters ranging from 48 to 72 nm were distributed on 3D-PU, facilitating its high BET surface area of 468.0 m2/g.
Wen-kui Li, Song Wang, Yong-hong Wang, Yu-zhen Wu, Jia Li, Tian-hua Chai, Kang Wang, GuangYou Chen, Zhiqing Ma   +8 more
openaire   +2 more sources

Toosendanin induces hepatotoxicity via disrupting LXRα/Lipin1/SREBP1 mediated lipid metabolism

Food and Chemical Toxicology
Toosendanin (TSN) is the main active compound derived from Melia toosendan Sieb et Zucc with various bioactivities. However, liver injury was observed in TSN limiting its clinical application. Lipid metabolism plays a crucial role in maintaining cellular homeostasis, and its disruption is also essential in TSN-induced hepatotoxicity.
Sixin Chen, Jiajie Ni, Li Luo, Jinxian Lin, Hongjie Peng, Feihai Shen, Zhiying Huang   +6 more
openaire   +2 more sources

Toosendanin inhibits T-cell proliferation through the P38 MAPK signalling pathway

European Journal of Pharmacology
In recent years, immunosuppressants have shown significant success in the treatment of autoimmune diseases. Therefore, there is an urgent need to develop additional immunosuppressants that offer more options for patients. Toosendanin has been shown to have immunosuppressive activity in vitro as well as effects on autoimmune hepatitis (AIH) in vivo ...
Ting Zhang, Xingyan Luo, Lin Jing, Chunfen Mo, Huijie Guo, Shuxia Yang, Yantang Wang, Ketian Zhao, Yi Lai, Yang Liu   +9 more
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Variability in response to toosendanin in a laboratory colony ofTrichoplusia ni

Phytoparasitica, 2007
Laboratory rearing of insects for scientific research ensures a constant supply of insects. However, laboratory colonies may diverge genetically and/or phenotypically from wild populations due to selection pressures in their artificial environment. This study examined how variation in a colony ofTrichoplusia ni influenced reproducibility over time of ...
Jennifer H. Cameron, Murray B. Isman, Mahesh K. Upadhyaya   +2 more
openaire   +1 more source

Cure of experimental botulism and antibotulismic effect of toosendanin.

Acta pharmacologica Sinica, 2004
Botulinum neurotoxins (BoNTs), a group of bacterial proteins that comprise a light chain disulfide linked a heavy chain, are the most lethal biotoxins known to mankind. By inhibiting neurotransmitter release, BoNTs cause severe neuroparalytic disease, botulism. A series of important findings in the past 10 years which displayed the molecular targets of
Yu-Liang, Shi, Zhong-Feng, Wang
openaire   +1 more source

Toosendanin induces hepatotoxicity by restraining autophagy and lysosomal function through inhibiting STAT3/CTSC axis

Toxicology Letters
Toosendanin (TSN) is the main active component in the traditional herb Melia toosendan Siebold & Zucc, which exhibits promising potential for development due to its diverse pharmacological properties. However, the hepatotoxicity associated with TSN needs further investigation.
Li, Luo, Jiajie, Ni, Jiahui, Zhang, Jinxian, Lin, Sixin, Chen, Feihai, Shen, Zhiying, Huang   +6 more
openaire   +2 more sources

Inhibition of large-conductance Ca2+-activated K+ channels in hippocampal neurons by toosendanin

Neuroscience, 2001
The effect of toosendanin, a selective presynaptic blocker and effective antibotulismic agent, on large-conductance Ca(2+)-activated K(+) channels was studied in inside-out patches of pyramidal neurons freshly isolated from the hippocampal CA1 region of the rat.
Z F, Wang, Y L, Shi
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Involvement of cytochrome c release and caspase activation in toosendanin-induced PC12 cell apoptosis

Toxicology, 2004
Our previous study showed that toosendanin, a triterpenoid derivative isolated from a Chinese traditional medicine, could induce apoptosis in PC12 cells. In this study we confirmed the apoptosis-inducing effect of toosendanin in PC12 cells with new evidences in morphology and biochemistry: the shrinkage of cytosol, the condensation and fragmentation of
Mian-Zhi, Tang, Zhong-Feng, Wang, Yu-Liang, Shi   +2 more
openaire   +2 more sources