Results 111 to 120 of about 492 (137)

Sensory responses to the triterpenoid antifeedant toosendanin

1992
One of the basic problems in insect-plant relationships is how insects can perceive thousands of different antifeedant compounds, many of them occurring in plants in only low concentrations, according to Jermy (1983) “host plant specificity in phytophagous insects is determined mainly by the botanical distribution of plant substances inhibiting feeding”
Luo Lin-er, Schoonhoven, L.M.
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Toosendanin Inhibits Hepatocellular Carcinoma Cells by Inducing Mitochondria-dependent Apoptosis

Planta Medica, 2010
Toosendanin, a triterpenoid derivative isolated from Melia toosendan Sieb. et Zucc., possesses different pharmacological effects in humans and an important value in agriculture. As indicated by previous reports, the molecular mechanisms of toosendanin's anticancer effects remain poorly clarified.
Yujuan, He, Jin, Wang, Xiaoling, Liu, Ling, Zhang, Gang, Yi, Chenwei, Li, Xiao, He, Peng, Wang, Hui, Jiang   +8 more
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Biological effects of toosendanin, a triterpenoid extracted from Chinese traditional medicine

Progress in Neurobiology, 2007
Toosendanin (TSN) is a triterpenoid extracted from Melia toosendan Sieb et Zucc, which was used as a digestive tract-parasiticide and agricultural insecticide in ancient China. TSN was demonstrated to be a selective presynaptic blocker and an effective antibotulismic agent.
Yu-Liang, Shi, Mu-Feng, Li
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Modulation of inward rectifier potassium channel by toosendanin, a presynaptic blocker

Neuroscience Research, 2001
The effect of toosendanin, a presynaptic blocker, on the inward rectifier potassium channel (K(Kir)) of hippocampal CA1 pyramidal neurons of rats was studied by the single-channel patch-clamp technique. The results showed that toosendanin had an inhibitory effect on K(Kir) in an excised inside-out patch of the neuron under a symmetrical 150 mM K ...
Z F, Wang, Y L, Shi
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Toosendanin: upgrade of an old agent in cancer treatment

Chinese Journal of Natural Medicines
Toosendanin (TSN), a tetracyclic triterpenoid derived from Melia toosendan and M. azedarach, demonstrates broad application prospects in cancer treatment. Although previously employed as a pesticide, recent studies have revealed its potential therapeutic value in treating various types of cancer. TSN exerts an anticancer effect via mechanisms including
Shuwei, Li, Qingyi, Xiong, Yiwen, Shen, Jiayi, Lin, Lijun, Zhang, Ye, Wu, Jinmei, Jin, Xin, Luan   +7 more
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Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy

Science Translational Medicine, 2023
T cell–based immunotherapy holds promise for treating solid tumors, but its therapeutic efficacy is limited by intratumoral immune suppression. This immune suppressive tumor microenvironment is largely driven by tumor-associated myeloid cells, including macrophages.
Fan Yang, Duo Zhang, Haowen Jiang, Jiangbin Ye, Lin Zhang, Stephen J. Bagley, Jeffery Winkler, Yanqing Gong, Yi Fan   +8 more
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Toosendanin induces outgrowth of neuronal processes and apoptosis in PC12 cells

Neuroscience Research, 2003
In the present study, the effects of toosendanin on cell differentiation and apoptosis were investigated in PC12 cells. The results showed that after 24-48 h of culture in a medium containing toosendanin (approximately 1-10x10(-7) M), cell differentiation and outgrowth of neuronal processes were promoted.
Mian-Zhi, Tang, Zhong-Feng, Wang, Yu-Liang, Shi   +2 more
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Toosendanin‐induced apoptosis of CMT‐U27 is mediated through the mitochondrial apoptotic pathway

Veterinary and Comparative Oncology, 2023
AbstractToosendanin (TSN) is an active compound from the fruit of Melia toosendan Sieb et Zucc. TSN has been shown to have broad‐spectrum anti‐tumour activities in human cancers. However, there are still many gaps in the knowledge of TSN on canine mammary tumours (CMT). CMT‐U27 cells were used to select the optimal acting time and best concentration of
Yin, Yang, Chen, Mei, Hong, Xian, Xue, Zhang, Jun, Li, Zhi-Xuan, Liang, Yan, Zhi, Yue, Ma, Hong-Jun, Wang   +8 more
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Action of toosendanin on the membrane current of mouse motor nerve terminals

Brain Research, 1993
By perineurial recording, the actions of toosendanin on three potassium currents and two calcium currents in the nerve terminal were observed in the intercostal nerve triangularis stein muscle of the mouse. Toosendanin partially blocked the voltage-dependent fast K+ current and irreversibly increased the voltage-dependent slow Ca2+ current.
Y, Xu, Y, Shi
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Effect of Toosendanin on acetylcholine level of rat brain, a microdialysis study

Brain Research, 1999
The effect of prejunctional blocker Toosendanin (TSN) on acetylcholine (ACh) level in striatum and parietal cortex was investigated by means of method of brain dialysis coupled with microbore high-performance liquid chromatograph (HPLC)-electrochemical detection (ECD) with enzyme immobilized post-column at freely moving rats. The results are as follows:
Y L, Shi, W Y, Chen
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