Results 51 to 60 of about 492 (137)

The role of programmed cell death in osteosarcoma: From pathogenesis to therapy

Cancer Medicine, Volume 13, Issue 10, May 2024.
Abstract Osteosarcoma (OS) is a prevalent bone solid malignancy that primarily affects adolescents, particularly boys aged 14–19. This aggressive form of cancer often leads to deadly lung cancer due to its high migration ability. Experimental evidence suggests that programmed cell death (PCD) plays a crucial role in the development of osteosarcoma ...
Suqing Liu, Chengtao Liu, Yian Wang, Jiewen Chen, Yujin He, Kaibo Hu, Ting Li, Junmei Yang, Jie Peng, Liang Hao   +9 more
wiley   +1 more source

The apoptotic effects of toosendanin are partially mediated by activation of deoxycytidine kinase in HL-60 cells.

PLoS ONE, 2012
Triterpenoid toosendanin (TSN) exhibits potent cytotoxic activity through inducing apoptosis in a variety of cancer cell lines. However, the target and mechanism of the apoptotic effects by TSN remain unknown.
Jianming Ju, Zhichao Qi, Xueting Cai, Peng Cao, Yan Huang, Shuzhen Wang, Nan Liu, Yijun Chen   +7 more
doaj   +1 more source

Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer

JCI Insight, 2022
The aberrant activation of STAT3 is associated with the etiology and progression in a variety of malignant epithelial-derived tumors, including head and neck squamous cell carcinoma (HNSCC) and colorectal cancer (CRC).
Jinmei Jin, Yaping Wu, Zeng Zhao, Ye Wu, Yu-dong Zhou, Sanhong Liu, Qingyan Sun, Guizhu Yang, Jiayi Lin, Dale G. Nagle, Jiangjiang Qin, Zhiyuan Zhang, Hong-zhuan Chen, Weidong Zhang, Shuyang Sun, Xin Luan   +15 more
doaj   +1 more source

Correction: Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3 [PDF]

Oncogene, 2019
Since the publication of this paper, the authors have noticed that the article contains an error in Figure 3e (TSN, 50 nM). As a result of the misfiling of the data, the incorrect image was inadvertently inserted in Figure 3e during figure preparation. The corrected image is shown in this correction.
Zhang, T., Li, J., Yin, F., Lin, B ., Wang, Z., Xu, J., Wang, H., Zuo, D., Wang, G., Hua, Y., Cai, Z.   +10 more
openaire   +1 more source

Plant‐derived compounds as potential leads for new drug development targeting COVID‐19

Phytotherapy Research, Volume 38, Issue 3, Page 1522-1554, March 2024.
Abstract COVID‐19, which was first identified in 2019 in Wuhan, China, is a respiratory illness caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Although some patients infected with COVID‐19 can remain asymptomatic, most experience a range of symptoms that can be mild to severe. Common symptoms include fever, cough,
Lingxiu Liu, Maxim Kapralov, Mark Ashton
wiley   +1 more source

Research on the Influence of Toosendanin on Endometrial Cancer by Regulating p27kip1 and Its Clinical Significance [PDF]

BIO Web of Conferences
Endometrial cancer, also known as uterine corpus cancer, is one of the malignant tumors in the female reproductive system. In recent years, its global incidence has been gradually increasing and showing a trend of younger onset, posing a potential major ...
Zhou Wenchu
doaj   +1 more source

In Silico Analysis of Limonoid-Based Antifeedants from Melia volkensii Targeting the Ryanodine Receptor in Spodoptera frugiperda

Sciences of Phytochemistry
Spodoptera frugiperda is an invasive pest causing significant crop losses worldwide. Resistance development and health and environmental concerns associated with synthetic insecticides have prompted a search for eco-friendly biopesticides. Limonoids such
Mohamed Said Rajab
doaj   +1 more source

The pre-synaptic blocker toosendanin does not inhibit secretion in exocrine cells

World Journal of Gastroenterology, 2002
Toosendanin is a pre-synaptic blocker at the neuromuscular junction and its inhibitory effect is divided into an initial facilitative/stimulatory phase followed by a prolonged inhibitory phase. The present study investigated whether the subsequent inhibitory phase was due to exhaustion of the secretory machinery as a result of extensive stimulation ...
Zong-Jie, Cui, Xue-Hui, He
openaire   +2 more sources

Toosendanin Suppresses Glioma Progression Property and Induces Apoptosis by Regulating miR-608/Notch Axis

Cancer Management and Research, 2020
Qiong Wang,1– 3 Zeng Wang,1– 3 Guilan Hou,1– 3 Ping Huang1– 3 1Department of Pharmacy, Institute of Cancer and Basic Medical Sciences of Chinese Academy of Sciences, Hangzhou City, Zhejiang Province 310022, People’s Republic
Wang Q, Wang Z, Hou G, Huang P
doaj  

Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade

Phytomedicine
The fruit of Melia toosendan Sieb. et Zucc. (MT) is known for its efficacy in relieving pain and treating roundworms. Toosendanin (TO) has been identified as a bioactive marker of MT, with hepatotoxic properties. This study offers a comprehensive investigation into the toxic mechanisms, involving TO-induced remaining DNA damage, cell cycle arrest, and ...
Yifan Lin, Jian Zhang, Xinyue Gao, Zekai Wu, Lele Yang, Kun Tian, Xiaoqi Lv, Jiaqi Li, Kunqi Chen, Youbo Zhang, Hong Hu, An Zhu   +11 more
openaire   +2 more sources