Results 41 to 50 of about 492 (137)
Veterinary Research, 2022 Porcine reproductive and respiratory syndrome virus (PRRSV) is a prevalent and endemic swine pathogen which causes significant economic losses in the global swine industry. Multiple vaccines have been developed to prevent PRRSV infection.
Mingxin Zhang +9 more
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BioMed Research International, Volume 2019, Issue 1, 2019., 2019 Currently, gastric cancer treatment is mainly based on first‐line intervention with oxaliplatin (OXA) after surgical resection, but the application of OXA has been limited due to the toxic side effects caused by the cumulative dose. The toxicity of OXA mainly includes hepatotoxicity, nephrotoxicity, and ototoxicity, and there is an urgent clinical need
Qi Li +8 more
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Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway [PDF]
Acta Pharmacologica Sinica, 2018 Toosendanin (TSN) is the main active compound in Toosendan Fructus and Meliae Cortex, two commonly used traditional Chinese medicines. TSN has been reported to induce hepatotoxicity, but its mechanism remains unclear. In this study, we demonstrated the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2) in protecting against TSN-induced
Yao, Jin +6 more
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Evidence-Based Complementary and Alternative Medicine, Volume 2019, Issue 1, 2019., 2019 Jinlingzi powder comprises Melia toosendan Sieb. et Zucc. and Corydalis yanhusuo (Y.H. Chou & Chun C.Hsu) W.T. Wang ex Z.Y. Su & C.Y. Wu and is usually applied in clinic as traditional Chinese medicine for pain. The present study aims to investigate the therapeutic actions of Jinlingzi powder and its extracted components and theirs treatment mechanism ...
Xueying Zhao +5 more
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Advanced Chinese Medicine, Volume 2, Issue 2, Page 62-84, June 2025.Schematic representation of the study design and methodology. Abstract Ethnopharmacological relevance Jinhong tablet (JHT), a traditional Chinese patent medicine prepared from four Chinese medicinal materials, is highly effective in soothing the liver and relieving depression, regulating qi and promoting blood circulation, and regulating the stomach ...
Tingyu Zhang +12 more
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Preclinical Models for Investigation of Herbal Medicines in Liver Diseases: Update and Perspective
Evidence-Based Complementary and Alternative Medicine, Volume 2016, Issue 1, 2016., 2016 Liver disease results from a dynamic pathological process associated with cellular and genetic alterations, which may progress stepwise to liver dysfunction. Commonly, liver disease begins with hepatocyte injury, followed by persistent episodes of cellular regeneration, inflammation, and hepatocyte death that may ultimately lead to nonreversible liver ...
Hor-Yue Tan +9 more
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Seven-Membered Lactam Derivatives of Podophyllotoxins as New Pesticidal Agents
Scientific Reports, 2017 As a continuation of our efforts to discover and develop natural-product-based insecticidal agents, three novel and unusual 7-membered lactam derivatives of podophyllotoxin were prepared by thionyl chloride-mediated ring-expanded Beckmann rearrangement ...
Xiaoyan Zhi +3 more
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The Phytochemical Composition of Melia volkensii and Its Potential for Insect Pest Management
Plants, 2020 Due to potential health and environmental risks of synthetic pesticides, coupled with their non-selectivity and pest resistance, there has been increasing demand for safer and biodegradable alternatives for insect pest management.
Victor Jaoko +9 more
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Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry
ChemistrySelect, Volume 9, Issue 27, July 18, 2024.Oximes are considered as versatile pharmacophores in discovery new class of medicinally active agents. The incorporation of hydroxylamine‐containing moieties to the carbonyl compounds can generate variety oximes. The current review focused on 49 reports, describing about various activities, including antimicrobial, anticancer, anti‐inflammatory ...
Namitha Chandran +13 more
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Molecules, 2018 The speciation of a methanolic extract of Zanthoxylum armatum stem bark has enabled the isolation and characterization of 11 known lignans. Among them, five compounds (6, 8–11) are reported in this plant for the first time. All of the chemical structures
Wenjuan Zhang +9 more
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