Results 21 to 30 of about 492 (137)
The Targeting of Noncoding RNAs by Quercetin in Cancer Prevention and Therapy
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 The dietary flavonoid quercetin is ubiquitously distributed in fruits, vegetables, and medicinal herbs. Quercetin has been a focal point in recent years due to its versatile health‐promoting benefits and high pharmacological values. It has well documented that quercetin exerts anticancer actions by inhibiting cell proliferation, inducing apoptosis, and
Man Wang +6 more
wiley +1 more source
STAT3 and its targeting inhibitors in osteosarcoma
Cell Proliferation, Volume 54, Issue 2, February 2021., 2021 Signal transducer and activator of transcription 3 (STAT3) is a member of the STAT protein family, vitally important for eukaryotic cells. We review the molecular structure and function of STAT3 and its isoforms, highlighting signalling pathways for the regulation of gene transcription. A critical appraisal of STAT3 in cancers, such as osteosarcoma, is
Yun Liu +7 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021 There is an increasing trend of investigating natural bioactive compounds targeting pancreatic β‐cells for the prevention/treatment of diabetes mellitus (DM). With the exploration of multiple mechanisms by which β‐cells involve in the pathogenesis of DM, herbal medicines are gaining attention due to their multitasking ability as evidenced by ...
Akurange Sujeevi Dammadinna Wickramasinghe +3 more
wiley +1 more source
Semisynthesis and insecticidal activity of some novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety [PDF]
Royal Society Open Science, 2017 Two series of novel fraxinellone-based thioethers containing 1,3,4-oxadiazole moiety were prepared as insecticidal agents against the oriental armyworm, Mythimna separata Walker. The structural assignment was based on the spectroscopic and X-ray analysis
Yong Guo +8 more
doaj +1 more source
Function-oriented synthesis applied to the anti-botulinum natural product toosendanin [PDF]
Bioorganic & Medicinal Chemistry, 2009 Botulinum neurotoxins (BoNTs) are the etiological agents responsible for botulism, a disease characterized by peripheral neuromuscular blockade and a characteristic flaccid paralysis of humans. The natural product toosendanin is a traditional Chinese medicine which has been reported to have anti-botulinum properties in animal models.
Yuya, Nakai +4 more
openaire +2 more sources
Five new limonoids isolated from Walsura robusta
Natural Products and Bioprospecting, 2023 Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1–4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) were isolated from the leaves of Walsura ...
Li Hou +8 more
doaj +1 more source
Effects of Toosendanin on Pregnancy and Uterine Immunity Alterations in Mice [PDF]
The American Journal of Chinese Medicine, 2010 This study was conducted to explore the abortifacient effect and the mechanisms of the Chinese herbal medicine component toosendanin, and to elucidate the significance of the Th1 cytokines IFN-γ and TNF-α, CD4+ and CD8+ T lymphocytes in the occurrence of abortion. Graded doses of toosendanin were given by intraperitoneal injection (i.p.) to mice at day
Jian-Lou, Zhang +7 more
openaire +2 more sources
Molecules, 2013 Toosendanin is the major bioactive component of Melia toosendan Sieb. et Zucc., which is traditionally used for treatment of abdominal pain and as an insecticide.
Na Li +4 more
doaj +1 more source
Frontiers in Pharmacology, 2019 Toosendanin (TSN) is a major bioactive component of Melia Fructus (MF) with anti-inflammatory, anti-botulinum, anti-microbial, and analgesic efficacy. Our previous study demonstrated that MF has anti-influenza A virus activity; however, the contribution ...
Young-Hee Jin +8 more
doaj +1 more source
Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3 [PDF]
Oncogene, 2017 Signal transducer and activator of transcription 3(STAT3) is an emerging target for cancer therapy. In this study, we identify Toosendanin (TSN) is an effective inhibitor of STAT3, leading to the impediment of various oncogenic processes in osteosarcoma.
Zhang, T +10 more
openaire +2 more sources