Screening of a Small Molecule Compound Library Identifies Toosendanin as an Inhibitor Against Bunyavirus and SARS-CoV-2 [PDF]
Frontiers in Pharmacology, 2021 Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus causing serious infectious disease with a high case-fatality of up to 50% in severe cases. Currently, no effective drug has been approved for the treatment of SFTSV
Shufen Li +10 more
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The therapeutic potential of natural products for treating pancreatic cancer [PDF]
Frontiers in Pharmacology, 2022 Pancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor prognosis and low 5-year survival rate less than 10%. Although surgical resection and chemotherapy as gemcitabine (first-line treatment) has been applied to the ...
Xia He +4 more
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Antitumor effect of toosendanin on oral squamous cell carcinoma via suppression of p-STAT3 [PDF]
BMC Oral Health, 2023 Background Toosendanin (TSN) exhibits potent antitumor activity against various tumor cell lines. However, its efficacy against oral squamous cell carcinoma (OSCC) remains unknown.
Ye Wu +6 more
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Limonoids From the Genus Melia (Meliaceae): Phytochemistry, Synthesis, Bioactivities, Pharmacokinetics, and Toxicology [PDF]
Frontiers in Pharmacology, 2022 Limonoids, as the vital bioactive chemical compounds in genus Melia plants, have attracted significant attention owing to their exclusive structural characteristics and remarkable biological activity.
Wenxiang Fan +4 more
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Toosendanin Induces Hepatotoxicity by Facilitating ALOX5-Mediated Lipid Peroxidation and Sensitizing Cells to Ferroptosis [PDF]
PharmaceuticalsBackground: Fructus Meliae Toosendan (FMT) is a traditional Chinese medicine used to treat ascariasis; however, its reported hepatotoxicity limits its application.
Jiajie Ni +6 more
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Toosendanin targeting eEF2 impedes Topoisomerase I & II protein translation to suppress esophageal squamous cell carcinoma growth [PDF]
Journal of Experimental & Clinical Cancer Research, 2023 Background Although molecular targets such as HER2, TP53 and PIK3CA have been widely studied in esophageal cancer, few of them were successfully applied for clinical treatment.
Xuechao Jia +15 more
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Toosendanin Attenuates Induced Pneumonia (MPP) in Mice via Inhibiting NF-κB-Mediated Inflammatory Response: In and Studies [PDF]
Dose-ResponseBackground In the present study, the therapeutic effects of Toosendanin (TSN) against Mycoplasma pneumoniae (MP)-induced pneumonia (MPP) in mice. Research Design Swiss albino mice were exposed to MP culture for 2 days, causing pneumonia, and then treated
Yin Zhou +4 more
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TSN Disrupts Fanconi Anemia Pathway Activation Through JAK/STAT1-Mediated Transcriptional Repression of FA Core Subunits in Bladder Cancer [PDF]
Dose-ResponseObjectives Resistance to platinum-based chemotherapy in bladder cancer is closely associated with activation of the Fanconi anemia (FA) DNA interstrand crosslink repair pathway.
Wenchao Zhao +3 more
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PLGA-based herb Toosendanin delivery system for efficient therapy of oral squamous cell carcinoma [PDF]
BMC Complementary Medicine and TherapiesOral squamous cell carcinoma (OSCC) is a significant public health issue worldwide. Conventional chemotherapeutic agents do not adequately meet the treatment demands because of their low efficacy and adverse side effects.
Lingling Chen +7 more
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A novel strategy for identifying hepatotoxic constituents in traditional Chinese medicine using dose-normalized intracellular accumulation as a cytotoxicity indicator: a case study of Jinlingzi San [PDF]
Frontiers in PharmacologyIntroductionHerb-induced liver injury associated with traditional Chinese medicine (TCM) has increasingly attracted scientific attention. However, the rapid and effective methods for elucidating the material basis of hepatotoxicity in TCM are still ...
Xiaoting Gu +6 more
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