Results 11 to 20 of about 492 (137)

miR‐106b‐5p protects against drug‐induced liver injury by targeting vimentin to stimulate liver regeneration [PDF]

MedComm
Understanding the endogenous mechanism of adaptive response to drug‐induced liver injury (arDILI) may discover innovative strategies to manage DILI. To gain mechanistic insight into arDILI, we investigated exosomal miRNAs in the adaptive response to ...
Xiaoyan Lu, Lingqi Yu, Jie Zheng, Anyao Li, Junying Li, He Lou, Wentao Zhang, Hui Guo, Yuzhen Wang, Xuemei Li, Yue Gao, Xiaohui Fan, Jürgen Borlak   +12 more
doaj   +3 more sources

Mechanisms involved in the anti-tumor effects of Toosendanin in glioma cells [PDF]

Cancer Cell International, 2021
Background Toosendanin (TSN) is a triterpenoid compound mainly used as an ascaris repellant. Recent studies have shown that it possesses antitumor effects in many types of tumor cells. However, the effects of TSN on glioma cells have rarely been reported.
Chaochao Zhang, Haijun Gao, Ziqiang Liu, Jiacheng Lai, Zhixin Zhan, Yong Chen, Haiyan Huang   +6 more
doaj   +4 more sources

Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction

Pharmaceuticals, 2022
Toosendanin (TSN) is a triterpenoid from the fruit or bark of Melia toosendan Sieb et Zucc, which has clear antitumor and insecticidal activities, but it possesses limiting hepatotoxicity in clinical application.
Li Luo, Yonghong Liang, Yuanyuan Fu, Zhiyuan Liang, Jinfen Zheng, Jie Lan, Feihai Shen, Zhiying Huang   +7 more
doaj   +3 more sources

Toosendanin Restrains Idiopathic Pulmonary Fibrosis by Inhibiting ZEB1/CTBP1 Interaction. [PDF]

Curr Mol Med
Background: Extensive deposition of extracellular matrix (ECM) in idiopathic pulmonary fibrosis (IPF) is due to hyperactivation and proliferation of pulmonary fibroblasts. However, the exact mechanism is not clear. Objective: This study focused on the role of CTBP1 in lung fibroblast function, elaborated its regulation mechanism, and analyzed the ...
Li X, Bai Z, Li Z, Wang J, Yan X.
europepmc   +3 more sources

Isolation and Characterization of an Anti-Osteoporotic Compound from Melia toosendan Fructus

Pharmaceutics, 2023
Melia toosendan fructus, traditionally employed in traditional Chinese and Korean herbal medicine, exhibits diverse biological properties encompassing anti-tumor, anti-inflammatory, and anti-viral effects.
Seong Cheol Kim, Dong Ryun Gu, Hyun Yang, Sung-Ju Lee, Jin Ah Ryuk, Hyunil Ha   +5 more
doaj   +1 more source

Toosendanin inhibits proliferation and promotes apoptosis of gastrointestinal stromal tumor-T1 cells by down-regulating c-kit expression

Di-san junyi daxue xuebao, 2021
Objective To investigate the effects of toosendanin (TSN) on the proliferation and apoptosis of gastrointestinal stromal tumor (GIST) cells, and to explore the underlying mechanisms. Methods GIST-T1 cells were treated with TSN at different concentrations,
HU Xiaoyu, HU Xiaoyu, YANG Wensheng, YANG Wensheng, KANG Zhengyu, KANG Zhengyu   +5 more
doaj   +1 more source

Toosendanin suppresses African swine fever virus replication through upregulating interferon regulatory factor 1 in porcine alveolar macrophage cultures

Frontiers in Microbiology, 2022
African swine fever virus (ASFV) is a highly infectious and lethal swine pathogen that causes severe socio-economic consequences in affected countries.
Yuanjia Liu, Xinheng Zhang, Zexin Liu, Li Huang, Weixin Jia, Xinlei Lian, Changjiang Weng, Guihong Zhang, Wenbao Qi, Jianxin Chen   +9 more
doaj   +1 more source

Synergistic Anti‐Tumor Effect of Toosendanin and Paclitaxel on Triple‐Negative Breast Cancer via Regulating ADORA2A‐EMT Related Signaling

Advanced Biology, Volume 7, Issue 8, August 2023., 2023
Triple negative breast cancer (TNBC) is an aggressive cancer with poor prognosis. Combo‐therapy shows promise in improving treatment efficacy. These results indicate that a natural product Toosendanin (TSN) potentiates paclitaxel (PTX)‐mediated anti‐tumor effects against TNBC.
Juan Zhang, Hong‐Xi Xu, Yu‐Lin Wu, William Chi Shing Cho, Yan‐Fang Xian, Zhi‐Xiu Lin   +5 more
wiley   +1 more source

Meliaceae genomes provide insights into wood development and limonoids biosynthesis

Plant Biotechnology Journal, Volume 21, Issue 3, Page 574-590, March 2023., 2023
The chromosome‐level genome of Azadirachta indica and Melia azedarach were provided. Meliaceae should be classified into two subfamilies: Cedreloideae and Melioideae. Cellulose/hemicellulose biosynthesis‐related genes expanded notably in woody Toona sinensis. Expanded special oxidosqualene cyclase catalogues help diversify Sapindales skeletons.
Gaofeng Cui, Yun Li, Xin Yi, Jieyu Wang, Peifan Lin, Cui Lu, Qunjie Zhang, Lizhi Gao, Guohua Zhong   +8 more
wiley   +1 more source

The Oral Wound Healing Potential of Thai Propolis Based on Its Antioxidant Activity and Stimulation of Oral Fibroblast Migration and Proliferation

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Introduction. Propolis has demonstrated wound healing effects. Propolis’ effects vary based on its composition and geographical origin. However, there are few reports on the effects of propolis on oral wound healing. The aim of this study was to evaluate the antioxidant and in vitro gingival wound healing effects of the n‐hexane extract of propolis ...
Suppanut Jongjitaree, Sittichai Koontongkaew, Nattisa Niyomtham, Boon-ek Yingyongnarongkul, Kusumawadee Utispan, Guoqiang Xing   +5 more
wiley   +1 more source