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Multi-Target Biological Activities of Podophyllotoxin-Derived Natural Products. [PDF]
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Current Protocols, 2021
AbstractTopoisomerases are enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of DNA topoisomerases: type I enzymes, which make single‐stranded cuts in DNA, and type II enzymes, which cut and decatenate double‐stranded DNA.
John L, Nitiss +4 more
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AbstractTopoisomerases are enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of DNA topoisomerases: type I enzymes, which make single‐stranded cuts in DNA, and type II enzymes, which cut and decatenate double‐stranded DNA.
John L, Nitiss +4 more
openaire +2 more sources
Current Opinion in Structural Biology, 1995
In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.
A, Sharma, A, Mondragón
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In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.
A, Sharma, A, Mondragón
openaire +2 more sources
EcoSal Plus, 2009
DNA topoisomerases are enzymes that control the topological state of DNA in all cells; they have central roles in DNA replication and transcription. They are classified into two types, I and II, depending on whether they catalyze reactions involving the breakage of one or both strands of DNA.
Katherine, Evans-Roberts +1 more
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DNA topoisomerases are enzymes that control the topological state of DNA in all cells; they have central roles in DNA replication and transcription. They are classified into two types, I and II, depending on whether they catalyze reactions involving the breakage of one or both strands of DNA.
Katherine, Evans-Roberts +1 more
openaire +2 more sources