Results 91 to 100 of about 67,641 (348)

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

Scientific Reports, 2015
With the diminishing effectiveness of current antibacterial therapies, it is critically important to discover agents that operate by a mechanism that circumvents existing resistance.
G. Basarab, G. Kern, J. McNulty, John P. Mueller, K. Lawrence, K. Vishwanathan, R. Alm, Kevin A Barvian, P. Doig, Vincent Galullo, H. Gardner, Madhusudhan R. Gowravaram, M. Huband, A. Kimzey, M. Morningstar, A. Kutschke, S. Lahiri, M. Perros, Renu Singh, Virna J. A. Schuck, R. Tommasi, G. Walkup, J. Newman   +22 more
semanticscholar   +1 more source

Transcriptional regulation of human topoisomerase II beta : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry [PDF]

, 2006
Pages 24 and 25 are missing from the original copy.Topoisomerase II has an essential role in maintaining the DNA in the correct topological state required for various cellular processes.
Mawson, Claire
core  

The causes and consequences of topological stress during DNA replication [PDF]

, 2016
The faithful replication of sister chromatids is essential for genomic integrity in every cell division. The replication machinery must overcome numerous difficulties in every round of replication, including DNA topological stress.
Andrea Keszthelyi, Champoux, Hiasa, Hiasa, Hiasa, Jonathan Baxter, Kornberg, Nicola Minchell   +7 more
core   +2 more sources

Cohesin causes replicative DNA damage by trapping DNA topological stress [PDF]

, 2020
DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress ...
Baxter, Jonathan, Keszthelyi, Andrea, Minchell, Nicola Elizabeth   +2 more
core   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Over-expression of Topoisomerase II Enhances Salt Stress Tolerance in Tobacco [PDF]

, 2016
Topoisomerases are unique enzymes having an ability to remove or add DNA supercoils and untangle the snarled DNA. They can cut, shuffle and religate DNA strands and remove the torsional stress during DNA replication, transcription or recombination events.
Badri N. Singh, Malireddy K. Reddy, Manchikatla V. Rajam, Riffat John, Sudhir K. Sopory, Tanushri Kaul, Uma Ganeshan   +6 more
core   +2 more sources

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

DNA topoisomerase inhibitors: biflavonoids from Ouratea species

Brazilian Journal of Medical and Biological Research, 2002
Topoisomerase inhibitors are agents with anticancer activity. 7"-O-Methyl-agathisflavone (I) and amentoflavone (II) are biflavonoids and were isolated from the Brazilian plants Ouratea hexasperma and O. semiserrata, respectively.
N.F. Grynberg, M.G. Carvalho, J.R. Velandia, M.C. Oliveira, I.C. Moreira, R. Braz- Filho, A. Echevarria   +6 more
doaj   +1 more source

Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914*

Journal of Biological Chemistry, 2015
Background: Inhibition of Neisseria gonorrhoeae type II topoisomerases gyrase and TopoIV by the antibacterial spiropyrimidinetrione AZD0914 was investigated.
G. Kern, T. Palmer, D. Ehmann, A. Shapiro, B. Andrews, G. Basarab, P. Doig, Jun Fan, Ning Gao, S. D. Mills, John D. Mueller, Shubha Sriram, Jason Thresher, G. Walkup   +13 more
semanticscholar   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source