Results 81 to 90 of about 23,598 (268)

Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. [PDF]

, 2018
Type IIA topoisomerases (Top2s) manipulate the handedness of DNA crossovers by introducing a transient and protein-linked double-strand break in one DNA duplex, termed the DNA-gate, whose opening allows another DNA segment to be transported through to ...
Chan, Nei-Li, Chen, Shin-Fu, Gilson, Michael K, Huang, Nan-Lan, Lin, Jung-Hsin, Wang, Ying-Ren, Wu, Chyuan-Chuan, Yu, Yu-Jen   +7 more
core   +2 more sources

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

DNA topoisomerase inhibitors: biflavonoids from Ouratea species

Brazilian Journal of Medical and Biological Research, 2002
Topoisomerase inhibitors are agents with anticancer activity. 7"-O-Methyl-agathisflavone (I) and amentoflavone (II) are biflavonoids and were isolated from the Brazilian plants Ouratea hexasperma and O. semiserrata, respectively.
N.F. Grynberg, M.G. Carvalho, J.R. Velandia, M.C. Oliveira, I.C. Moreira, R. Braz- Filho, A. Echevarria   +6 more
doaj   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Knotting probabilities after a local strand passage in unknotted self-avoiding polygons

, 2011
We investigate the knotting probability after a local strand passage is performed in an unknotted self-avoiding polygon on the simple cubic lattice.
Bates A, Berg B, Berger J M, Berretti A, Buck G, Burnier Y, C E Soteros, Clisby N, de Carvalho C A, de Carvalho C A, Fishman G S, Fogg J M, Gelman A, Gelman A, Guttmann A J, Hua X, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Liu Z, Liu Z, Liu Z, Liu Z R, M L Szafron, Manturov V, Marcone B, Orlandini E, Orlandini E, Orlandini E, Rybenkov V V, Shaw S Y, Sokal A D, Sumners D W, Szafron M L, Szafron M L, Trigueros S, Vologodskii A, Yan J   +38 more
core   +1 more source

Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases [PDF]

, 2016
DNA topology plays essential roles in several fundamental biological processes, such as DNA replication, recombination, and transcription. Typically agarose gel electrophoresis is employed to study DNA topology.
Berrido, Andrea, Chambers, Jeremy W., Gonzalez, Walter, Gu, Maxwell, Leng, Fenfei, Miksovska, Jaroslava   +5 more
core   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Unzipping DNA - towards the first step of replication

, 1999
The opening of the Y-fork - the first step of DNA replication - is shown to be a critical phenomenon under an external force at one of its ends. From the results of an equivalent delocalization in a non-hermitian quantum-mechanics problem we show the ...
Bhattacharjee, Somendra M.
core   +1 more source

TDP1/TOP1 ratio as a promising indicator for the response of small cell lung cancer to topotecan [PDF]

, 2014
BACKGROUND AND OBJECTIVE Small cell lung cancer (SCLC) is one of the most challenging tumors to treat due to high proliferation rate, early metastatic dissemination and rapid development of chemotherapy resistance.
El-Khamisy, Sherif F, Meisenberg, Cornelia, Schmid, Peter, Ward, Simon E   +3 more
core   +3 more sources

Topoisomerases in kinetoplastids

Parasitology Today, 1996
Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes.
C, Burri, A L, Bodley, T A, Shapiro
openaire   +2 more sources