Results 91 to 100 of about 16,235 (248)

Regulation of Bacterial Type IIA Topoisomerases [PDF]

, 2013
Regulation of Bacterial Type IIA Topoisomerases by Seychelle Monique Vos Doctor of Philosophy in Molecular and Cell Biology University of California, Berkeley Professor James M.
Vos, Seychelle Monique
core  

Expression of DNA topoisomerases in chronic proliferative kidney disease [PDF]

, 2000
Expression of DNA topoisomerases in chronic proliferative kidney disease.BackgroundCirculating autoantibodies to human topoisomerases have been reported in glomerular kidney disease associated with scleroderma and systemic lupus erythematosus.
Kellner, Udo, Jürgensen, Anja, Proppe, Dietfrid, Ivanova, Lilija V., Rudolph, Pierre, Tareeva, Irina E., Alm, Per   +6 more
core   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Two type I topoisomerases maintain DNA topology in human mitochondria [PDF]

Genetic processes require the activity of multiple topoisomerases, essential enzymes that remove topological tension and intermolecular linkages in DNA. We have investigated the subcellular localisation and activity of the six human topoisomerases with a
Rodríguez-Luis A, Deen D, Di Leo V, Austin CA, Cowell IG, Díaz-Maldonado H, Nicholls TJ, Casement JW, Menger KE, Chapman J, Erdinc D, Pyle A, Falkenberg M, Khazeem MM   +13 more
core   +4 more sources

Topoisomerases

, 2015
Capítulo en: Ram S. Verma (ed.). Advances in Genome Biology, vol. 5B. [S.l.]: JAI Press, 1998, p.463-486. ISBN 0-7623-0079-5. ISBN 978-0-7623-0079-2This chapter describes topoisomerases.
Roca, Joaquim
core  

Untangling bacterial DNA topoisomerases functions

International audienceTopoisomerases are the main enzymes capable of resolving the topological constraints imposed by DNA transactions such as transcription or replication. All bacteria possess topoisomerases of different types.
Espéli, Olivier, Bruno, Lisa, Borde, Céline   +2 more
core   +1 more source

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

UBE3A Dosage Imbalance as a Molecular Framework Linking Angelman Syndrome and Dup15q‐Associated Autism Phenotypes

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT UBE3A is a dosage‐sensitive HECT E3 ubiquitin ligase whose neuronal expression is shaped by genomic imprinting at the 15q11.2‐q13 locus. Opposite directions of UBE3A dosage imbalance contribute to distinct neurodevelopmental phenotypes: loss of maternal UBE3A underlies Angelman syndrome, whereas maternally derived 15q11.2‐q13 copy‐number gains,
Ruslan Kurmashev
wiley   +1 more source

Editorial: Mechanisms of Preservation and Change in Archaeal Genomes

Frontiers in Microbiology, 2021
Dennis W. Grogan
doaj   +1 more source