Results 91 to 100 of about 23,598 (268)

The causes and consequences of topological stress during DNA replication [PDF]

, 2016
The faithful replication of sister chromatids is essential for genomic integrity in every cell division. The replication machinery must overcome numerous difficulties in every round of replication, including DNA topological stress.
Andrea Keszthelyi, Champoux, Hiasa, Hiasa, Hiasa, Jonathan Baxter, Kornberg, Nicola Minchell   +7 more
core   +2 more sources

Arabidopsis thaliana GYRB3 does not encode a DNA gyrase subunit.

PLoS ONE, 2010
BackgroundDNA topoisomerases are enzymes that control the topology of DNA in all cells. DNA gyrase is unique among the topoisomerases in that it is the only enzyme that can actively supercoil DNA using the free energy of ATP hydrolysis.
Katherine M Evans-Roberts, Christian Breuer, Melisa K Wall, Keiko Sugimoto-Shirasu, Anthony Maxwell   +4 more
doaj   +1 more source

Identification and characterization of the orf virus type I topoisomerase [PDF]

, 1995
Vaccinia virus (VV) and Shope fibroma virus (SFV), representatives of the orthopox and leporipox genera, respectively,encode type I DNA topoisomerases.
Nancy Klemperer, David J. Lyttle, Dominique Tauzin, Paula Traktman, Anthony J. Robinson, Bauer, Brill, Champoux, D'Arpa, DeLange, Fernandez-Beros, Fleming, Fleming, Fogelsong, Fraser, Goebel, Gupta, Higgins, Kim, Klemperer, Laemmu, Liu, Lynn, Mercer, Moore, Morham, Morham, Moss, Osheroff, Rigby, Rosel, Sanger, Schultz, Shaffer, Shuman, Shuman, Shuman, Shuman, Shuman, Shuman, Shuman, Shuman, Studier, Thrash, Traktman, Traktman, Traktman, Uemura, Upton, Vogelstein, Wang, Wang   +51 more
core   +5 more sources

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Long‐Term Outcomes of Reduced‐Intensity Conditioning Hematopoietic Stem Cell Transplantation for Patients With Systemic Sclerosis With Impaired Cardiac Function

Arthritis &Rheumatology, EarlyView.
Objective High‐intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced systemic sclerosis (SSc). The role of reduced‐intensity conditioning (RIC) before AHSCT in this population remains unclear.
Yonatan Lean, Carrie Richardson, Anthony J. Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

Therapeutic potential of the phosphino Cu(I) complex (HydroCuP) in the treatment of solid tumors [PDF]

, 2017
[Cu(thp)4][PF6] (HydroCuP) is a phosphino copper(I) complex highly soluble and stable in physiological media that has been developed as a possible viable alternative to platinum-based drugs for anticancer therapy.
Ceresa, Cecilia, Esposito, Giovanni, Gandin, Valentina, Indraccolo, Stefano, Marzano, Cristina, Pellei, Maura, Porchia, Marina, Santini, Carlo, Tisato, Francesco   +8 more
core   +3 more sources

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Over-expression of Topoisomerase II Enhances Salt Stress Tolerance in Tobacco [PDF]

, 2016
Topoisomerases are unique enzymes having an ability to remove or add DNA supercoils and untangle the snarled DNA. They can cut, shuffle and religate DNA strands and remove the torsional stress during DNA replication, transcription or recombination events.
Badri N. Singh, Malireddy K. Reddy, Manchikatla V. Rajam, Riffat John, Sudhir K. Sopory, Tanushri Kaul, Uma Ganeshan   +6 more
core   +2 more sources

Consistency and clarity of pharmacogenomic guidance in UK medicine patient information leaflets: A cross‐sectional analysis

British Journal of Clinical Pharmacology, EarlyView.
Pharmacogenomic (PGx) information has the potential to support the safe and effective use of medicines, yet there is uncertainty about how this information can be best communicated to patients. Summaries of product characteristics (SmPCs) and patient information leaflets (PILs) for all UK‐approved medicines with strong evidence supporting a PGx ...
Parth Narlawar, Chloe Ratcliffe, Videha Sharma, William G. Newman, Munir Pirmohamed, John McDermott   +5 more
wiley   +1 more source

Supercoiled DNA: Structure [PDF]

, 2015
Supercoiling is introduced into DNA molecules when the double helix is twisted around its own axis in three‐dimensional space. Experimental techniques that are sensitive to molecular shape can be used to analyse the topological states of DNA, but the ...
Bowater, Richard
core   +1 more source