Results 101 to 110 of about 16,235 (248)

Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks

Cell Reports, 2016
During transcription and DNA replication, the DNA template is overwound ahead of RNA and DNA polymerases and relaxed by DNA topoisomerases. Inhibitors of topoisomerases are potent anti-cancer agents.
Cyril Ribeyre, Ralph Zellweger, Maeva Chauvin, Nicole Bec, Christian Larroque, Massimo Lopes, Angelos Constantinou   +6 more
doaj   +1 more source

E. coli DNA topoisomerases.

, 2019
E. coli DNA topoisomerases.
Zhong Qian (8119712), Subhash C. Verma (8119709), Sankar L. Adhya (8119715)   +2 more
core   +1 more source

Two type I topoisomerases maintain DNA topology in human mitochondria

, 2022
Genetic processes require the activity of multiple topoisomerases, essential enzymes that remove topological tension and intermolecular linkages in DNA. We have investigated the subcellular localisation and activity of the six human topoisomerases with a
Erdinc, Direnis,, Deen, D., Pyle, Angela, Austin, C. A., Cowell, I. G., Chapman, James, Rodríguez-Luis, Alejandro, Menger, K. E., Khazeem, M. M., Casement, J. W., Austin, Caroline A, Cowell, Ian G, Di Leo, V., Nicholls, Thomas J, Díaz-Maldonado, Héctor, Deen, Dasha, Menger, Katja E, Nicholls, T. J., Casement, John W, Di Leo, Valeria, Chapman, J., Khazeem, Mushtaq M, Erdinc, Direnis, Falkenberg, Maria, Falkenberg, Maria,, Diaz-Maldonado, Hector,, Rodriguez-Luis, A., Pyle, A.   +27 more
core   +1 more source

Structural insights into the DNA topoisomerase II of the African swine fever virus

Nature Communications
Type II topoisomerases are ubiquitous enzymes that play a pivotal role in modulating the topological configuration of double-stranded DNA. These topoisomerases are required for DNA metabolism and have been extensively studied in both prokaryotic and ...
Jingyuan Cong, Yuhui Xin, Huiling Kang, Yunge Yang, Chenlong Wang, Dongming Zhao, Xuemei Li, Zihe Rao, Yutao Chen   +8 more
doaj   +1 more source

The Topopyrones Poison Human DNA Topoisomerases I and II

, 2016
The Topopyrones Poison Human DNA Topoisomerases I and ...
Mark A. Elban (515828), Sidney M. Hecht (1305729), Qasim A. Khan (2417008)   +2 more
core   +1 more source

Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases [PDF]

, 2016
DNA topology plays essential roles in several fundamental biological processes, such as DNA replication, recombination, and transcription. Typically agarose gel electrophoresis is employed to study DNA topology.
Miksovska, Jaroslava, Leng, Fenfei, Gonzalez, Walter, Chambers, Jeremy W., Gu, Maxwell, Berrido, Andrea   +5 more
core   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Application of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VI.

PLoS ONE, 2013
DNA topoisomerases are highly exploited targets for antimicrobial drugs. The spread of antibiotic resistance represents a significant threat to public health and necessitates the discovery of inhibitors that target topoisomerases in novel ways.
James A Taylor, Lesley A Mitchenall, Martin Rejzek, Robert A Field, Anthony Maxwell   +4 more
doaj   +1 more source

Plant DNA Topoisomerases: Structure, Function, and Cellular Roles in Plant Development

, 2004
Regulation of the topological state of DNA is critical for cellular viability. DNA topoisomerases alter DNA topology and participate in nearly all events related to DNA metabolism such as replication, transcription, recombination, and chromosome ...
S. K. Sopory, Reddy, M. K., B. N. Singh, M. K. Reddy, Sopory, S. K., Singh, B. N.   +5 more
core   +1 more source

Topoisomerases facilitate transcription of long genes linked to autism [PDF]

, 2013
Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown.
Joel S. Parker, Hsiao, Jack S., Benjamin D. Philpot, Parker, Joel S., Zylka, Mark J., Chandri N. Yandava, Mark J. Zylka, Pearson, Brandon L., Terry Magnuson, Jack S. Hsiao, Chamberlain, Stormy J., Hsien-Sung Huang, Joshua Starmer, Yandava, Chandri N., Huang, Hsien-Sung, Starmer, Joshua, Stormy J. Chamberlain, Brandon L. Pearson, Philpot, Benjamin D., J. Mauro Calabrese, Mabb, Angela M., Ian F. King, Angela M. Mabb, King, Ian F., Calabrese, J. Mauro, Magnuson, Terry   +25 more
core   +1 more source