Results 201 to 210 of about 67,641 (348)

Type IA topoisomerases can be “magicians” for both DNA and RNA in all domains of life

RNA Biology, 2017
Muzammil Ahmad, Dongyi Xu, Weidong Wang
semanticscholar   +1 more source

Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors

, 2015
Lemao Yu, Xiaoru Zhang, Xiaobing Li, Yuan Yang, Hongyu Wei, Xixin He, Lian‐Quan Gu, Zhi‐Shu Huang, Yves Pommier, Lin‐Kun An   +9 more
openalex   +1 more source

Therapy‐Related Acute Myeloid Leukemia Following Plasma Cell Leukemia: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT With the improvement of survival in multiple myeloma (MM), therapy‐related acute myeloid leukemia (t‐AML) has emerged as a clinically relevant second primary malignancy (SPM). We report a case of MM evolving into t‐AML after multi‐agent chemotherapy and review the literature on therapy‐related leukemias in MM.
Songdi Chen, Junqing Hu, Qian Zhang, Luling Mao, Qian Jiang, Chuyun Qian, Weize Zhang, Keting Jin, Jianhu Li, Ji‐nuo Wang, Yi Zhao   +10 more
wiley   +1 more source

Mechanistic basis for relaxation of DNA supercoils by human topoisomerase IIIα-RMI1-RMI2. [PDF]

Proc Natl Acad Sci U S A
Spakman D, Biebricher AS, Bizard AH, Hickson ID, Peterman EJG, Wuite GJL, King GA.   +6 more
europepmc   +1 more source

A Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non–Small Cell Lung Cancer Cell Lines

, 2015
Iryna O. Zubovych, Anirudh Sethi, Aditya Kulkarni, Vural Tagal, Michael G. Roth   +4 more
openalex   +1 more source

Safety and Efficacy of Concomitant Administration of Nanoliposomal Irinotecan + 5‐Fluorouracil/Levo‐Leucovorin for Pancreatic Cancer

Cancer Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Nanoliposomal irinotecan (nal‐IRI) plus 5‐fluorouracil (5‐FU)/levo‐leucovorin (Levo‐LV) therapy is recommended as the standard of care for unresectable locally advanced (UR‐LA) and metastatic pancreatic cancer after failure of gemcitabine‐containing regimens.
Akane Wakabayashi, Rei Tanaka, Yurie Fukumuro, Keita Mori, Junya Sato, Hiroshi Ishikawa, Michihiro Shino, Takeshi Kawakami   +7 more
wiley   +1 more source

Drugging topoisomerases: lessons and challenges.

ACS Chemical Biology, 2013
Y. Pommier
semanticscholar   +1 more source

Molecular and cellular effects of the combined treatment with Camptothecin and Roscovitine in human lung and colon adenocarcinoma cells [PDF]

, 2008
De Mattia, Roberta
core   +1 more source

Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Their bioactive constituents act through antioxidant, anti‐inflammatory, and metabolic‐regulating mechanisms, validating their classification as functional foods. Evidence from clinical and biochemical studies largely supports these benefits, although some claims stem from preliminary or in vitro findings.
Nighat Raza, Alina Sadaf, Reeha Mushtaq, Mirza Abid Mehmood, Luqman Amrao, Fakhar Islam, Muhammad Afzaal, Mohd Asif Shah   +7 more
wiley   +1 more source

Direct trapping of the transport-segment DNA by the central domain of type IIA topoisomerases. [PDF]

Sci Adv
Xin Y, Xian R, Liu C, Zhang O, Rao Z, Li X, Chen Y.   +6 more
europepmc   +1 more source