Results 61 to 70 of about 67,641 (348)

Data of transcriptional effects of the merbarone-mediated inhibition of TOP2

Data in Brief, 2022
Type II DNA topoisomerases relax topological stress by transiently gating DNA passage in a controlled cut-and-reseal mechanism that affects both DNA strands.
Fernando M. Delgado-Chaves, Pedro Manuel Martínez-García, Andrés Herrero-Ruiz, Francisco Gómez-Vela, Federico Divina, Silvia Jimeno-González, Felipe Cortés-Ledesma   +6 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Knotting probabilities after a local strand passage in unknotted self-avoiding polygons

, 2011
We investigate the knotting probability after a local strand passage is performed in an unknotted self-avoiding polygon on the simple cubic lattice.
Bates A, Berg B, Berger J M, Berretti A, Buck G, Burnier Y, C E Soteros, Clisby N, de Carvalho C A, de Carvalho C A, Fishman G S, Fogg J M, Gelman A, Gelman A, Guttmann A J, Hua X, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Liu Z, Liu Z, Liu Z, Liu Z R, M L Szafron, Manturov V, Marcone B, Orlandini E, Orlandini E, Orlandini E, Rybenkov V V, Shaw S Y, Sokal A D, Sumners D W, Szafron M L, Szafron M L, Trigueros S, Vologodskii A, Yan J   +38 more
core   +1 more source

DNA unzipped under a constant force exhibits multiple metastable intermediates [PDF]

, 2003
Single molecule studies, at constant force, of the separation of double-stranded DNA into two separated single strands may provide information relevant to the dynamics of DNA replication.
Bockelmann, Bustamante, Bustamante, C. Bouzigues, C. Danilowicz, D. K. Lubensky, D. R. Nelson, Essevaz-Roulet, Gosse, Isralewitz, Le Doussal, Liphardt, Lubensky, M. Prentiss, Marenduzzo, M  chali, Quake, Rief, Rouzina, SantaLucia, Sebastian, Smith, Strick, Strick, Thomen, V. W. Coljee, Vermeer   +26 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life

Cells
Topoisomerases regulate the topological state of cellular genomes to prevent impediments to vital cellular processes, including replication and transcription from suboptimal supercoiling of double-stranded DNA, and to untangle topological barriers ...
Kemin Tan, Yuk-Ching Tse-Dinh
doaj   +1 more source

Unveiling the interdomain dynamics of type II DNA topoisomerase through all-atom simulations: Implications for understanding its catalytic cycle

Computational and Structural Biotechnology Journal, 2023
Type IIA DNA topoisomerases are complex molecular nanomachines that manage topological states of the DNA molecule in the cell and play a crucial role in cellular processes such as cell division and transcription.
Matic Pavlin, Barbara Herlah, Katja Valjavec, Andrej Perdih   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Our Evolving Understanding of the Mechanism of Quinolones

Antibiotics, 2018
The maintenance of DNA supercoiling is essential for the proper regulation of a plethora of biological processes. As a consequence of this mode of regulation, ahead of the replication fork, DNA replication machinery is prone to introducing supercoiled ...
Arnaud Gutierrez, Jonathan M. Stokes, Ivan Matic   +2 more
doaj   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source