Results 81 to 90 of about 63,915 (257)

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Quantum mirror curve of periodic chain geometry

Journal of High Energy Physics, 2019
The mirror curves enable us to study B-model topological strings on noncompact toric Calabi-Yau threefolds. One of the method to obtain the mirror curves is to calculate the partition function of the topological string with a single brane. In this paper,
Taro Kimura, Yuji Sugimoto
doaj   +1 more source

SO(10) Cosmic Strings and SU(3) Color Cheshire Charge

, 1993
Certain cosmic strings that occur in GUT models such as $SO(10)$ can carry a magnetic flux which acts nontrivially on objects carrying $SU(3)_{color}$ quantum numbers.
A. Balachandran, A. Barut, A. Everett, A. Everett, A. S. Schwarz, A. Sommerfeld, A. Stern, A. Vilenkin, Alfred S. Goldhaber, B. Julia, C. P. Ma, D. Arovas, D. Olive, D. Peak, E. Witten, F. Bais, F. Bais, F. Bais, F. Wilczek, F. Wilzcek, H. Carslaw, H. Carslaw, H. K. Lo, J. Preskill, J. Preskill, L. Perivolaropoulos, M. Alford, M. Alford, M. Alford, M. Alford, M. Alford, M. Alford, M. Alford, M. Aryal, M. Born, M. Bucher, M. Bucher, M. Bucher, Martin Bucher, R. Sundrum, T. Kibble, T. Skyrme, T. T. Wu, V. Poenaru, W. Perkins, Y. Aharonov   +45 more
core   +1 more source

Topological Strings and Quantum Spectral Problems [PDF]

, 2014
We consider certain quantum spectral problems appearing in the study of local Calabi-Yau geometries. The quantum spectrum can be computed by the Bohr-Sommerfeld quantization condition for a period integral.
Huang, Min-xin, Wang, Xian-fu
core   +2 more sources

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Selection rules of topological solitons from non-invertible symmetries in axion electrodynamics

Journal of High Energy Physics
We investigate a relation between non-invertible symmetries and selection rules of topological solitons such as axionic domain walls and magnetic strings in the (3 + 1)-dimensional axion electrodynamics with a massive axion or a massive photon.
Yoshimasa Hidaka, Muneto Nitta, Ryo Yokokura   +2 more
doaj   +1 more source

Compactifying String Topology

, 2011
55 pages, 7 ...
Poirier, Kate, Rounds, Nathaniel
openaire   +2 more sources

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Non-spinning tops are stable

Journal of High Energy Physics
We consider coupled gravitational and electromagnetic perturbations of a family of five-dimensional Einstein-Maxwell solutions that describes both magnetized black strings and horizonless topological stars.
Iosif Bena, Giorgio Di Russo, Jose Francisco Morales, Alejandro Ruipérez   +3 more
doaj   +1 more source

Quantum periods and TBA-like equations for a class of Calabi-Yau geometries

Journal of High Energy Physics, 2021
We continue the study of a novel relation between quantum periods and TBA(Thermodynamic Bethe Ansatz)-like difference equations, generalize previous works to a large class of Calabi-Yau geometries described by three-term quantum operators.
Bao-ning Du, Min-xin Huang
doaj   +1 more source