Results 91 to 100 of about 25,866 (210)

Reduction of severe visual loss and complications following intra-arterial chemotherapy (IAC) for refractory retinoblastoma. [PDF]

, 2017
BACKGROUND: Intra-arterial chemotherapy (IAC) for retinoblastoma has been documented as causing visual loss and ocular motility problems. A lack of safety data has precluded its acceptance in all centres.
Duncan, C, Herod, J, Liasis, A, Naeem, Z, Reddy, MA, Rennie, A, Robertson, F, Sagoo, M, Thompson, DA   +8 more
core   +1 more source

Topotecan and Ginkgolic Acid Inhibit the Expression and Transport Activity of Human Organic Anion Transporter 3 by Suppressing SUMOylation of the Transporter

Pharmaceutics
Organic anion transporter 3 (OAT3), expressed at the basolateral membrane of kidney proximal tubule cells, facilitates the elimination of numerous metabolites, environmental toxins, and clinically important drugs.
Zhou Yu, Guofeng You
doaj   +1 more source

The role of topotecan in cancer ginecology treatment

Опухоли женской репродуктивной системы, 2017
The high morbidity, often latent, asymptomatic disease development is not optimal therapy in the first line, causes the development of the frequent recurrence of tumors, requiring second and thirds lines of chemotherapy.
A. G. Kedrova, V. V. Kosyy, D. A. Astakhov   +2 more
doaj   +1 more source

FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance [PDF]

, 2015
International audienceAbstractBackgroundIrinotecan is a camptothecin analogue currently used in clinical practice to treat advanced colorectal cancer. However, acquired resistance mediated by the drug efflux pump ABCG2 is a recognized problem.
Celine Gongora, Chunyang Jin, David Westover, Fengzhi Li, Hong Lam, Jacob Welch, Maguy Del Rio, Mansukh Wani, Xiang Ling   +8 more
core   +3 more sources

Phase I dose escalation study of vinorelbine and topotecan combination chemotherapy in patients with recurrent lung cancer

BMC Cancer, 2007
Background A platinum doublet is the current standard treatment for good performance status patients with advanced non-small cell lung cancer (NSCLC) and extensive stage small cell lung cancer (SCLC) with good performance status.
Kraft Andrew S, Meyer Mario L, Chaudhary Uzair, Garrett-Mayer Elizabeth, Green Mark R, Sherman Carol A, Beldner Matthew A, Montero Alberto J   +7 more
doaj   +1 more source

Therapie bei Progression und Rezidiv des Ovarialkarzinoms [PDF]

, 2000
Secondary surgery after failure of primary treatment is a promising and reasonable option only for patients with a relapse-free interval of at least 6-12 months who should have ideally achieved a tumor-free status after primary therapy.
Burges, A., Gropp, M., Hepp, H., Meier, W.   +3 more
core   +1 more source

A comparison of clinical pharmacodynamics of different administration schedules of oral topotecan (Hycamtin) [PDF]

, 1999
Prolonged exposure to topotecan in in vitro and in vivo experiments has yielded the highest antitumor efficacy. An oral formulation of topotecan with a bioavailability of 32-44% in humans enables convenient prolonged ...
Beurden, V.M. (Vera) van, Burg, M.E.L. (Maria) van der, Burris, H. (Howard), Eckardt, J.R., Gerrits, C.J.H., Hudson, I., Loos, W.J. (Walter), Planting, A.S.Th. (André), Rodriguez, G.I., Schellens, J.H.M. (Jan), Verweij, J. (Jaap), Von Hoff, D.D. (Daniel)   +11 more
core   +1 more source

Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma [PDF]

, 2015
PURPOSE:To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment.METHODS:A panel of two ...
Abramson, David, Arana, Eloisa, Buitrago, Emiliano, Chantada, Guillermo Luis, Croxatto, Juan Oscar, del Sole, Maria Jose, Djaballah, Hakim, Francis, Jasmine, Laurent, Viviana Eunice, Mena, Hebe Agustina, Negrotto, Soledad, Schaiquevich, Paula Susana, Sgroi, Mariana, Winter, Ursula Andrea   +13 more
core   +2 more sources

Heparin and Liver Heparan Sulfate Can Rescue Hepatoma Cells from Topotecan Action [PDF]

, 2014
Topotecan (TpT) is a major inhibitory compound of topoisomerase (topo) I that plays important roles in gene transcription and cell division. We have previously reported that heparin and heparan sulfate (HS) might be transported to the cell nucleus and ...
Baghy, Kornélia, Bocsi Jozsef, Dudas Jozsef, Fuele Tibor, Fullár, Alexandra, Kovalszky, Ilona, Kudaibergenova Saule   +6 more
core   +3 more sources

Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models

Neoplasia: An International Journal for Oncology Research, 2005
To investigate the cellular/molecular basis of the activity of a novel lipophilic camptothecin, gimatecan (ST1481), against slowly proliferating cells, we performed a comparative study of topotecan and gimatecan in human bladder cancer models (HT1376 and
Paola Ulivi, Wainer Zoli, Francesco Fabbri, Giovanni Brigliadori, Luca Ricotti, Anna Tesei, Marco Rosetti, Michelandrea De Cesare, Giovanni L. Beretta, Elisabetta Corna, Rosanna Supino, Franco Zunino   +11 more
doaj   +1 more source