Results 71 to 80 of about 25,866 (210)

Current study concepts for refractory ovarian carcinoma [PDF]

, 1998
Second-line and recurrence therapy in advanced ovarian carcinoma is at present based more on clinical empiricism than on data from prospective comparative studies.
Meier, Werner
core   +1 more source

A Novel FGFR3‐Targeting Antibody‐Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS–STING Pathway in Bladder Cancer

Advanced Science, Volume 13, Issue 4, 19 January 2026.
LZU‐WZLYCS01 is a novel FGFR3‐targeting ADC for bladder cancer with 7‐ethyl‐9‐fluorocamptothecin (A2) as its cytotoxic payload. LZU‐WZLYCS01 intracellularly releases A2, which targets MAD2L1 to activate the cGAS‐STING pathway and induce tumor cell apoptosis.
Shu Cui, Xiongfei Luo, Guangrui Fan, Jingqi Jiang, Yingru Wang, Enguang Yang, Jinpeng Ma, Ze Zhang, Yuhan Wang, Juan Wang, Dengtuo Wang, Hanzhang Wang, Liang Cheng, Junqiang Tian, Zhilong Dong, Yingqian Liu, Zhiping Wang   +16 more
wiley   +1 more source

Pharmacokinetics and pharmacodynamics of topotecan administered daily for 5 days every 3 weeks [PDF]

, 1995
Topotecan is a novel semisynthetic derivative of the anticancer agent camptothecin and inhibits the intranuclear enzyme topoisomerase I. The lactone structure of topotecan, which is in equilibrium with the inactive ringopened hydroxy acid, is essential ...
Beijnen, J.H. (Jos), Boer-Dennert, M. (Maureen) de, Davies, B.E. (Brian), Maes, R. (Rudolf), Rosing, H. (Hilde), Schellens, J.H.M. (Jan), Verweij, J. (Jaap), Warmerdam, L.J. (Laurence) van   +7 more
core   +1 more source

Machine Learning Integration Framework Constructs a Lactylation‐Associated Gene Signature to Improve Prognosis in Bladder Cancer

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Bladder cancer remains a significant challenge in oncology owing to its high recurrence rates and limited treatment options, particularly in cases of resistance to standard therapies. Aims Our study aimed to pinpoint a lactylation‐associated gene signature capable of predicting prognosis and providing important theoretical support ...
Jingsong Wang, Qianxue Lu, Panpan Jiao, Jun Jian, Qingyuan Zheng, Zhiyuan Chen, Xiuheng Liu, Shanshan Wan, Lei Wang   +8 more
wiley   +1 more source

A Real‐World Analysis of Outcomes in CIC‐Rearranged Sarcomas: A Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC) Study

Cancer Medicine, Volume 15, Issue 1, January 2026.
Chemotherapy was not associated with improved survival in localized or metastatic CIC‐rearranged sarcoma. Optimizing local control remains essential, and novel systemic therapies are urgently needed. ABSTRACT Introduction CIC‐rearranged sarcomas (CRS) are rare tumors predominantly affecting young adults.
Talya Wittmann Dayagi, Hagit Peretz Soroka, Alannah Smrke, Rebecca J. Deyell, Xiaolan Feng, Sapna Oberoi, Shantanu Banerji, Jonathan Noujaim, Nicolas Prud'homme, Ramy Saleh, Omar Farooq Khan, Jonathan Willard Bush, Bilal Marwa, Geoffrey Watson, Caroline Holloway, Lingxin Zhang, Abha Anshu Gupta, Jack Brzezinski   +17 more
wiley   +1 more source

Topotecan lacks third space sequestration [PDF]

, 2000
The objective of this study was to determine the influence of pleural and ascitic fluid on the pharmacokinetics of the antitumor camptothecin derivative topotecan.
Gelderblom, A.J. (Hans), Jonge, M.J.A. (Maja) de, Loos, W.J. (Walter), Sparreboom, A. (Alex), Verweij, J. (Jaap)   +4 more
core   +1 more source

Mathematical model of brain tumour with glia-neuron interactions and chemotherapy treatment [PDF]

, 2015
Acknowledgements This study was possible by partial financial support from the following Brazilian government agencies: Fundação Araucária, EPSRC-EP/I032606/1 and CNPq, CAPES and Science Without Borders Program Process nos. 17656125, 99999.010583/2013-00
Baptista, Murilo Da Silva, Baptista, Murilo S., Batista, Antonio M., Borges, Fernando S., Iarosz, Kelly C., Lopes, Sergio R., Siqueira, Regiane A. N., Viana, Ricardo L.   +7 more
core   +1 more source

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source

Sustained Complete Response after Maintenance Therapy with Topotecan and Erlotinib for Recurrent Cervical Cancer with Distant Metastases

Case Reports in Oncology, 2014
Introduction: Recurrent cervical cancer is associated with a poor prognosis. Most treatment responses are partial and of short duration. The development of new therapies is vital to improve treatment for recurrent disease.
Donato Callegaro-Filho, John J. Kavanagh, Alpa M. Nick, Pedro T. Ramirez, Kathleen M. Schmeler   +4 more
doaj   +1 more source

The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling [PDF]

, 2017
Background: Renal cell carcinomas (RCCs) display broad resistance against conventional radio- and chemotherapies, which is due at least in part to impairments in both extrinsic and intrinsic apoptotic pathways. One important anti-apoptotic factor that is
Funke, Sarah, Gasis, Marcia, Hanenberg, Helmut, Heikaus, Sebastian, Liverts, Anna, Mahotka, Csaba, Nitsche, Vanessa, Schirmacher, Peter, Toth, Csaba, Wiek, Constanze, Zlachevska, Viktoriya   +10 more
core   +1 more source