Results 81 to 90 of about 25,866 (210)
ChemMedChem, Volume 21, Issue 2, January 2026.Natural products and/or their structural analogs represent the greatest number of approved small‐molecules as antitumor agents. We report the synthesis of 2‐propanamide and 2‐propanamine dihydrobenzopyrans and 2‐ and 2,3‐disubstituted quinolines to evaluate their cytotoxicity against human A549 (lung), A2058 (melanoma), HepG2 (liver), MCF‐7 (breast ...
Bernabeu‐Sanchis Álvaro +8 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2020 While topotecan (TPT) is a first- and second-line chemotherapeutic drug in treating lung cancer, the development of drug resistance in tumors still reserves as a major obstacle to chemotherapeutic success.
Zi-Ning Lei +12 more
doaj +1 more source
Effects of camptothecin derivatives and topoisomerase dual inhibitors on Trypanosoma cruzi growth and ultrastructure [PDF]
, 2014 BACKGROUND: Trypanosoma cruzi is the etiological agent of Chagas’ disease that is an endemic disease in Latin America and affects about 8 million people.
Aline Araujo Zuma +4 more
core +1 more source
Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei +11 more
wiley +1 more source
The suppression of DNA repair induced by PARP-1 inhibitors rucaparib and olaparib in combination with the radiopharmaceutical 131I-MIBG in noradrenaline transporter-expressing xenograft tumors [PDF]
, 2018 No abstract ...
Gaze, Mark N. +4 more
core +1 more source
Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.TANs drive ICI resistance via antitumour immune remodelling, angiogenesis promotion, and elevation of tumour mutation burden Neutrophil biomarkers (e.g., NLR, TAN abundance) show strong predictive value for ICI response and prognosis. Targeting TAN recruitment, polarization, function and NETosis represents a promising strategy to overcome ICI ...
Ying Ning +7 more
wiley +1 more source
Pharmaceuticals, 2020 Topotecan is actively used in clinic, with its primary use being in treatment of various types of cancer. The approved administration routes are oral and intravenous.
Seung-Hyun Jeong +2 more
doaj +1 more source
Radiosensitization of prostate cancer cells by 2-deoxyglucose [PDF]
, 2018 Prostate cancer is the most common malignancy of men. Treatment options include radiotherapy with or without hormonal manipulation and radical prostatectomy. However, there is no effective treatment for disseminated disease.
Mairs, R.J., Rae, C., Sey, C.H.C.
core
Dose banding as an alternative to body surface area-based dosing of chemotherapeutic agents [PDF]
, 2012 Background: Dose banding is a recently suggested dosing method that uses predefined ranges (bands) of body surface area (BSA) to calculate each patients dose by using a single BSA-value per band.
Baker, S.D. (Sharyn) +5 more
core +1 more source
Bevacizumab in ovarian cancer: Clinical data and predictive and prognostic biomarkers
Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.Evidence supporting bevacizumab in ovarian cancer and predictive biomarkers: highlighting opportunities to improve patient selection and advance personalised treatment strategies. Abstract Angiogenesis, driven by the vascular endothelial growth factor (VEGF)/VEGFR signalling axis under hypoxic conditions, is one of the hallmarks of ovarian cancer (OC),
Maria Rosaria Lamia +6 more
wiley +1 more source