Results 1 to 10 of about 19,670 (79)

Everolimus as a therapeutic option in refractory epilepsy in children with tuberous sclerosis: a systematic review

Arquivos de Neuro-Psiquiatria, 2023
Background Tuberous sclerosis (TS) is a multisystem genetic disease in which epilepsy is a frequent manifestation and is often difficult to control. Everolimus is a drug with proven efficacy in the treatment of other conditions related to TS, and some ...
Catarina Ester Gomes Menezes, Débora Lopes dos Santos, Erick Santos Nery, Evelin Duarte Serpa, Lécio Aragão Souza Morais, Lucas Santana Dutra, Marcos Baruch Portela Filho, Julieta Sobreira Goes   +7 more
doaj   +1 more source

The Role of Mammalian Target of Rapamycine Signaling Pathway in Central Nervous System Cancers: A Review

The Journal of Qazvin University of Medical Sciences, 2021
Mammalian Target Of Rapamycine (mTOR) is a conserved serine/threonine kinase in the PI3K/Akt/ mTOR signaling pathway. This pathway is regulated by changes in cells such as change in energy level, growth factors, and stressful conditions as well as ...
Forough Alemi Serej, Hosein Aliyari Serej, Abbas Ebrahimi Kalan, Ahmad Mehdipour, Zeynab Aliyari Serej, Balal Bravan, Mohammad Reza Shiri shahsavar   +6 more
doaj   +1 more source

Advancements in the diagnosis and treatment of renal epithelioid angiomyolipoma: A narrative review

Kaohsiung Journal of Medical Sciences, 2022
Renal epithelioid angiomyolipoma (EAML) is a unique subtype of angiomyolipoma that contains a variety of cytoplasmic‐rich, eosinophilic cytoplasm epithelioid cells in addition to mature adipocytes, hyaline thick‐walled vessels, and smooth muscle‐like ...
Jian‐Wei Yang, Cheng Liang, Li Yang
doaj   +1 more source

Alternative Polyadenylation in Human Diseases [PDF]

Endocrinology and Metabolism, 2017
Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing.
Jae-Woong Chang, Hsin-Sung Yeh, Jeongsik Yong   +2 more
doaj   +1 more source

The Anti-Obesity and Anti-Steatotic Effects of Chrysin in a Rat Model of Obesity Mediated through Modulating the Hepatic AMPK/mTOR/lipogenesis Pathways

Molecules, 2023
Background: Obesity is a complex multifactorial disease characterized by excessive adiposity, and is linked to an increased risk of nonalcoholic fatty liver disease (NAFLD).
Ghaleb Oriquat, Inas M. Masoud, Maher A. Kamel, Hebatallah Mohammed Aboudeya, Marwa B. Bakir, Sara A. Shaker   +5 more
doaj   +1 more source

Gene expression during the formation of resting spores induced by nitrogen starvation in the marine diatom Chaetoceros socialis

BMC Genomics, 2023
Background Dormancy is widespread in both multicellular and unicellular organisms. Among diatoms, unicellular microalgae at the base of all aquatic food webs, several species produce dormant cells (spores or resting cells) that can withstand long periods
Angela Pelusi, Luca Ambrosino, Marco Miralto, Maria Luisa Chiusano, Alessandra Rogato, Maria Immacolata Ferrante, Marina Montresor   +6 more
doaj   +1 more source

Association of Genetic Variations in The PIK3-AKT-mTOR Pathway with Endometriosis Susceptibility: A Preliminary Case-Control Study [PDF]

International Journal of Fertility and Sterility
Background: Endometriosis is a complex, heterogeneous disease with several genetic and non-genetic pathogenic fac­tors. The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway may influence both ...
Rahele Ghasemian Moghadam, Forough Forghani, Danial Jahantigh, Saeedeh Ghazaey Zidanloo, Mahnaz Rezaei, Mohsen Taheri   +5 more
doaj   +1 more source

Pretreatment of artesunate promoted hepatocyte proliferation by activating the PI3K/Akt/mTOR signaling pathway in mice [PDF]

Acta Cirúrgica Brasileira
Purpose: Artesunate (ART) has been implicated in regulating the many processes of liver injury, but its roles in liver regeneration still need to be illustrated.
Changyou Lu, Xinkai Li, Chao Fang, Chuntao Li, Yunke Xu, Yong Guo   +5 more
doaj   +1 more source

THADA inhibits autophagy and increases 5-FU sensitivity in gastric cancer cells via the PI3K/AKT/mTOR signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): 5-Fluorouracil (5-FU) is currently the main drug used in chemotherapy for gastric cancer (GC). The main clinical problems of 5-FU therapy are insensitivity and acquired resistance to 5-FU.
Xianke Lin, Jiajia Pan, Hammza Hamoudi, Jiren Yu   +3 more
doaj   +1 more source

Sugar metabolism and the plant Target Of Rapamycin kinase: a sweet operaTOR?

Frontiers in Plant Science, 2013
In eukaryotes, the ubiquitous TOR (Target Of Rapamycin) kinase complexes have emerged as central regulators of cell growth and metabolism. The plant TOR complex 1 (TORC1), that contains evolutionary conserved protein partners, has been shown to be ...
Thomas eDobrenel, Chloé eMarchive, Marianne eAzzopardi, Gilles eClément, Manon eMoreau, Rodnay eSormani, Christophe eRobaglia, Christian eMeyer   +7 more
doaj   +1 more source