Results 171 to 180 of about 2,397 (210)

OATP1B1 polymorphisms and torsemide pharmacokinetics and pharmacodynamics

, 2007
Nuernberg, P., Schirmer, Markus Anton, Vormfelde, Stefan Viktor, Meineke, Ingolf, Brockmoeller, Juergen, Toliat, Mohammad Reza   +5 more
core  

OATP1B1 polymorphisms and torsemide pharmacokinetics and pharmacodynamics

, 2018
Vormfelde, Stefan Viktor, Toliat, Mohammad Reza, Schirmer, Markus Anton, Meineke, Ingolf, Nuernberg, P., Brockmoeller, Juergen   +5 more
openaire   +1 more source

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Torsemide: A new loop diuretic

American Journal of Health-System Pharmacy, 1995
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of torsemide are reviewed. Torsemide belongs to the pyridine-sulfonylurea class of loop diuretics. Its primary site of activity is the thick ascending limb of the loop of Henle, where it blocks active reabsorption of sodium and chloride, resulting in ...
S F, Fowler, K M, Murray
exaly   +4 more sources

Torsemide inhibits aldosterone secretion in vitro

Life Sciences, 1998
Torsemide inhibited aldosterone secretion by adrenal cells from rats, cows, and guinea pigs stimulated in vitro by potassium, angiotensin, dibutyryl cyclic AMP, ACTH, or corticosterone. Inhibitory concentrations for adrenal cells (micromolar) were comparable with those reported to inhibit ion transport in isolated renal tubules.
Theodore L Goodfriend, Dennis L Ball, D L Ball   +2 more
exaly   +3 more sources

An evaluation of torsemide in patients with heart failure and renal disease

Expert Review of Cardiovascular Therapy, 2022
Torsemide is a loop diuretic that inhibits the Na+/K+/2Cl- cotransporter type 2 in the thick ascending loop of Henle, leading to increased excretion of urinary sodium and chloride and associated diuresis. While furosemide remains the dominant diuretic utilized in current practice, increasing evidence supports potential advantages of torsemide in heart ...
Anthony E Peters, Robert J Mentz, Tracy A Dewald   +2 more
exaly   +3 more sources

Evaluation of the effect of torsemide on warfarin dosage requirements

International Journal of Clinical Pharmacy, 2017
Background According to drug interaction databases, torsemide may potentiate the effects of warfarin. Evidence for this drug-drug interaction, however, is conflicting and the clinical significance is unknown. Objective The aim of this study is to evaluate the impact of torsemide initiation on warfarin dosage requirements.
Jeremiah D Momper, Felix K Yam, Momper Jeremiah D   +2 more
exaly   +3 more sources

Effects of oral administration of furosemide and torsemide in healthy dogs [PDF]

American Journal of Veterinary Research, 2007
Abstract Objective—To investigate the diuretic effects, tolerability, and adverse effects of furosemide and torsemide after short- and long-term administration in healthy dogs. Animals—8 mixed-breed dogs. Procedures—In a crossover study, furosemide (2 mg/kg), torsemide (0.2 mg/kg), or placebo (bifidobacterium [1 mg/kg]) was administered orally to each ...
Yasutomo, Hori, Fumihiko, Takusagawa, Hiromi, Ikadai, Masami, Uechi, Fumio, Hoshi, Sei-ichi, Higuchi   +5 more
openaire   +3 more sources

Torsemide Crystalline Salts with a Significant Spring-Parachute Effect

AAPS PharmSciTech
Torsemide is a long acting pyridine sulfonylurea diuretic. Torsemide hydrochloride is widely used now, there are only a few organic acid salts reported. Cocrystallization with organic acids is an effective way to improve its solubility. Here, we reported maleate and phthalate of torsemide, in which the organic acid lost a proton transferring to the ...
Kun Qian
exaly   +3 more sources

Effect of Torsemide Versus Furosemide on Symptoms and Quality of Life Among Patients Hospitalized for Heart Failure: The TRANSFORM-HF Randomized Clinical Trial [PDF]

Circulation, 2023
Stephen J Greene, Eric J Velázquez, Robert M Clare   +2 more
exaly   +2 more sources