Results 51 to 60 of about 4,707,483 (329)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Frontiers in NutritionBackgroundHigh sodium intake and fluid overhydration are common factors of and strongly associated with adverse outcomes in chronic kidney disease (CKD) patients. Yet, their effects on cardiac dysfunction remain unclear.AimsThe study aimed to explore the
Suyan Duan +10 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Annales Academiae Medicae SilesiensisIntroduction: The principles of optimal perioperative fluid therapy in thoracic surgery have been discussed for many years due to its possible role in pulmonary complications.
Piotr Wichary +5 more
doaj +1 more source
Acta Universitatis Carolinae Kinanthropologica, 2015 This study was designed to determine the influence of 6 weeks’ MonaVie juice supplementation on body composition and hydration status in young elderly physically active women.
Ilona Pokora +3 more
doaj +1 more source
Heliyon, 2021 Background: This study estimated total body water (TBW), daily water intake (DWI) and haemoglobin-haematocrit relationship in adults in a tropical environment where active lifestyles could precipitate plasma volume contraction.
Grace Ali-Baya +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Total body water and recurrent atrial fibrillation
Терапевтический архив, 2011 Aim. To specify the relationship between content of total body water and recurrent atrial fibrillation (AF) of non-valvular etiology. Material and methods.
Maksim Vital'evich Menzorov +5 more
doaj
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The Clinical Respiratory JournalIntroduction Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurrent upper airway collapse, resulting in intermittent hypoxia and sleep fragmentation.
Mucahit Yetim +4 more
doaj +1 more source