Results 51 to 60 of about 1,146,764 (302)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Are Ethnic and Gender Specific Equations Needed to Derive Fat Free Mass from Bioelectrical Impedance in Children of South Asian, Black African-Caribbean and White European Origin? Results of the Assessment of Body Composition in Children Study

, 2013
Background Bioelectrical impedance analysis (BIA) is a potentially valuable method for assessing lean mass and body fat levels in children from different ethnic groups.
Cook Derek G., Whincup, PH, Derek G Cook, Furness Cheryl A., Newton Sian L., Alicja R Rudnicka, Claire M. Nightingale (168851), Rudnicka Alicja R., Newton, SL, Howard Emma L., Sian L. Newton (474108), Gillings, RD, Whincup Peter H., Sian L Newton, Jonathan C K Wells, Furness, CA, Peter H. Whincup (168892), Wells, JC, Donin, AS, Angela S. Donin (179825), Howard, EL, Cheryl A Furness, Gillings Rachel D., Jonathan C. K. Wells (112583), Rudnicka, AR, Angela S Donin, Rachel D Gillings, Emma L. Howard (474110), Donin Angela S., Derek G. Cook (168879), Cheryl A. Furness (474109), Nightingale Claire M., Nightingale, CM, Wells Jonathan C. K., Owen Christopher G., Owen, CG, Rachel D. Gillings (474111), Cook, DG, Claire M Nightingale, Emma L Howard, Christopher G. Owen (168863), Alicja R. Rudnicka (168859), Christopher G Owen, Peter H Whincup   +43 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Effect of water restriction on drinking behaviour and water intake in German black-head mutton sheep and Boer goats

Animal, 2012
The present study was conducted to evaluate and compare the physiological responses of sheep and goats to water restriction using the deuterium dilution technique (D2O) to predict the total water intake (TWI) in both species.
D. Al-Ramamneh, A. Riek, M. Gerken
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparison of the Watson formula and bioimpedance spectroscopy for measuring body volume and calculating kt/V in patients with peritoneal dialysis

Renal Failure
Background Ascertaining the total body water (V), usually obtained by the Watson formula or bioimpedance spectroscopy (BIS), is crucial for the calculation of Kt/V in patients with peritoneal dialysis (PD).
Sixiu Liu, Yuan Feng, Qingyan Zhang, Jian Lu, Nan Li, Ying Liu, Chunming Jiang   +6 more
doaj   +1 more source

Deuterium oxide dilution accurately predicts water intake in sheep and goats

Animal, 2010
The aim of this study was to test whether the deuterium oxide dilution technique accurately predicts water intake in sheep and goats. Two other issues were also studied: (i) a comparison of water intake in sheep and goats and (ii) an assessment of ...
D. Al-Ramamneh, A. Riek, M. Gerken
doaj   +1 more source

Studies on seasonal variation in metabolic rate related to changes in body composition with particular reference to shorebirds (Charadrii) [PDF]

, 1992
The basal metabolic rate of three species of shorebird was measured throughout the non-breeding season. These measurements were related to change in body mass and body composition.
Scott, Ian Alexander
core  

Changes in total body water in infants receiving total intravenous nutrition [PDF]

, 1979
Using deuterium oxide dilution technique, the total body water changes of five infants maintained on total parenteral nutrition have been determined. While average weight gains of from 14 to 53 g/day were documented, there were decreases in percentage ...
Polley, Jr. , Theodore Z., Weintraub, William H., Benner, Jon W., Coran, Arnold G., Rhodin, Anders   +4 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source