Results 71 to 80 of about 1,146,764 (302)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Water and sodium intake habits and status of ultra-endurance runners during a multi-stage ultra-marathon conducted in a hot ambient environment: an observational field based study

Nutrition Journal, 2013
Background Anecdotal evidence suggests ultra-runners may not be consuming sufficient water through foods and fluids to maintenance euhydration, and present sub-optimal sodium intakes, throughout multi-stage ultra-marathon (MSUM) competitions in the heat.
Costa Ricardo JS, Teixeira Ana, Rama Luis, Swancott Abigail JM, Hardy Lisa D, Lee Benjamin, Camões-Costa Vera, Gill Samantha, Waterman Jessica P, Freeth Emily C, Barrett Edel, Hankey Joanne, Marczak Slawomir, Valero-Burgos Encarna, Scheer Volker, Murray Andrew, Thake Charles D   +16 more
doaj   +1 more source

Anthropometric and physiological changes in elite female water polo players during a training year

, 2008
The aim of the current study was to monitor physiological and anthropometric characteristics of elite female water polo players within the periodized training year. Fourteen subjects participated in the current study.
Marrin, K., Marrin, Kelly, Bampouras, Theodoros, Bampouras, T.   +3 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Validity of Body Composition Estimates in Women Assessed by a Multifrequency Bioelectrical Impedance Device

Sensors
Background: Multifrequency bioelectrical impedance devices such as the InBody 770 (IB770) offer faster measurements and lower costs compared with other body composition assessments.
Mitchell E. Zaplatosch, Juliana F. Meireles, Janeen S. Amason, Sadaf Dabeer, Brian M. Kliszczewicz, Gerald T. Mangine, Valene G. Barry, Barbara A. Gower, Katherine H. Ingram   +8 more
doaj   +1 more source

Association between the content of intracellular and extracellular fluid and the amount of water intake among Chinese college students

Nutrition & Metabolism, 2019
Background Normal distribution of body fluid is important for maintaining health through the balance of water metabolism. Studies have shown that disease states and diuretics perturb the balance and then induce abnormal intracellular/extracellular fluid ...
Na Zhang, Jianfen Zhang, Songming Du, Hairong He, Xinyu Yan, Guansheng Ma   +5 more
doaj   +1 more source

Measurement of total body water (TBW) and total energy expenditure (TEE) using stable isotopes

, 2011
Understanding the relationship between diet, physical activity and health in humans requires accurate measurement of body composition and daily energy expenditure. Stable isotopes provide a means of measuring total body water and daily energy expenditure
Wishart, Cornelia
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Pollution effects on body mass distributions of freshwater benthic communities

, 2010
Theoretical studies of the resilience of ecological systems to environmental change predict that the size distributions of species in ecosystems should have discontinuities that reflect similar discontinuities in ecosystem processes.
Bibi, Hamida
core