Results 81 to 90 of about 4,707,483 (329)

Reduction in cardiovascular risk by sodium-bicarbonated mineral water in moderately hypercholesterolemic young adults. [PDF]

, 2010
Effects of drinking a sodium bicarbonated mineral water on cardiovascular risk in young men and women with moderate cardiovascular risk were studied. Eighteen young volunteers, total cholesterol levels >5.2 mmol/L without any disease participated.
Navas-Carretero, S. (Santiago), Pérez-Granados, A.M. (Ana M.), Schoppen, S. (Stefanie), Vaquero, M.P. (M. Pilar)   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Body composition data from the rat subjects of Cosmos 1129 experiment K-316 [PDF]

The effects of 18.5 days of weightlessness on the body composition of young, growing, male laboratory rats were examined. Three groups of 5 rats each were examined. It is indicated that exposure of young, growing, male rats to 18.5 days of weightlessness
Pace, N., Pitts, G. C., Smirnova, T. A., Smith, A. H., Ushakov, A. S.   +4 more
core   +1 more source

Effects of glycerol and creatine hyperhydration on doping-relevant blood parameters [PDF]

, 2012
Glycerol is prohibited as an ergogenic aid by the World Anti-Doping Agency (WADA) due to the potential for its plasma expansion properties to have masking effects.
Catherine Hambly, Chris Easton, Craig, Dalia Malkova, Dill, Easton, Fjeld, Freund, Gore, Green, Hagan, Harris, Haugland, Holland, John R. Speakman, Karsten Koehler, Kavouras, Kilduff, Latzka, Lukas Beis, Lyons, Morkeberg, Pantazis Takas, Parisotto, Polyviou, Riedesel, Schumacher, Sharpe, Sommer, Sottas, Speakman, Thelma P. Polyviou, Vandenberghe, Yannis P. Pitsiladis   +33 more
core   +3 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Water and sodium intake habits and status of ultra-endurance runners during a multi-stage ultra-marathon conducted in a hot ambient environment: an observational field based study

Nutrition Journal, 2013
Background Anecdotal evidence suggests ultra-runners may not be consuming sufficient water through foods and fluids to maintenance euhydration, and present sub-optimal sodium intakes, throughout multi-stage ultra-marathon (MSUM) competitions in the heat.
Costa Ricardo JS, Teixeira Ana, Rama Luis, Swancott Abigail JM, Hardy Lisa D, Lee Benjamin, Camões-Costa Vera, Gill Samantha, Waterman Jessica P, Freeth Emily C, Barrett Edel, Hankey Joanne, Marczak Slawomir, Valero-Burgos Encarna, Scheer Volker, Murray Andrew, Thake Charles D   +16 more
doaj   +1 more source

Skylab water balance error analysis [PDF]

Estimates of the precision of the net water balance were obtained for the entire Skylab preflight and inflight phases as well as for the first two weeks of flight.
Leonard, J. I.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Validity of Body Composition Estimates in Women Assessed by a Multifrequency Bioelectrical Impedance Device

Sensors
Background: Multifrequency bioelectrical impedance devices such as the InBody 770 (IB770) offer faster measurements and lower costs compared with other body composition assessments.
Mitchell E. Zaplatosch, Juliana F. Meireles, Janeen S. Amason, Sadaf Dabeer, Brian M. Kliszczewicz, Gerald T. Mangine, Valene G. Barry, Barbara A. Gower, Katherine H. Ingram   +8 more
doaj   +1 more source