Results 61 to 70 of about 6,456 (262)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Estimating total body water in neonates [PDF]

Archives of Disease in Childhood - Fetal and Neonatal Edition, 1998
Editor—The body weight of the preterm babies in the study by Tang et al predicted the total body water better than any other single anthropomorphic measure, and that it accounted for 99% of the variations seen in body water measurements.1 The authors then used a variety of other measurements and anthropomorphic characteristics and combined them in a ...
openaire   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Skeletal Muscle Mass Measured Noninvasively by D3-Creatine Dilution in Children and Term Infants

Journal of Pediatrics: Clinical Practice
Objective: To measure the longitudinal changes in body composition including muscle mass (MM), total body water (TBW), and body fat in term infants and children using the D3Creatine (D3Cr) dilution method combined with 2H2O.
Mahalakshmi Shankaran, PhD, Brian Scottoline, MD, PhD, Faryal Imam, MD, Kelly Garton, MS, Jacob Lohr, MD, Edna Nyangau, MS, Hussein Mohammed, BS, Marc Hellerstein, MD, PhD, William J. Evans, PhD   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Comparison of the values of measured hydratation of sporting youths with normative values

Acta Universitatis Palackianae Olomucensis. Gymnica, 2013
BACKROUND: When measuring body composition, we monitor the fractionalization of body weight and the share of the individual elements in its aggregate value. The total body water (TBW) is a very important element in addition to the share of body fat (BF),
Petr Kutáč
doaj  

Effect of Fluid Intake on Acute Changes in Plasma Volume: A Randomized Controlled Crossover Pilot Trial

Metabolites
Plasma volume (PV) undergoes constant and dynamic changes, leading to a large intra-day variability in healthy individuals. Hydration is known to induce PV changes; however, the response to the intake of osmotically different fluids is still not fully ...
Janis Schierbauer, Sabrina Sanfilippo, Auguste Grothoff, Ulrich Fehr, Nadine Wachsmuth, Thomas Voit, Paul Zimmermann, Othmar Moser   +7 more
doaj   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Wearable Devices Based on Bioimpedance Test in Heart-Failure: Design Issues

Reviews in Cardiovascular Medicine
Heart-failure (HF) is a severe medical condition. Physicians need new tools to monitor the health status of their HF patients outside the hospital or medical supervision areas, to better know the evolution of their patients’ main biomarker values ...
Santiago F. Scagliusi, Luis Giménez-Miranda, Pablo Pérez-García, Alberto Olmo-Fernández, Gloria Huertas-Sánchez, Francisco J. Medrano-Ortega, Alberto Yúfera-García   +6 more
doaj   +1 more source