Results 91 to 100 of about 366,581 (319)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Maximum Number of Minimum Dominating and Minimum Total Dominating Sets
, 2013 Given a connected graph with domination (or total domination) number \gamma>=2, we ask for the maximum number m_\gamma and m_{\gamma,T} of dominating and total dominating sets of size \gamma.
Godbole, Anant +2 more
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Total Roman {3}-Domination: The Complexity and Linear-Time Algorithm for Trees [PDF]
, 2021 Xinyue Liu +3 more
openalex +1 more source
Signed total domination in graphs
Discrete Mathematics, 2004 The paper continues the study of the signed total domination in graphs which was started by the reviewer. Let \(G\) be a graph with vertex set \(V\). For each \(v\in V\) let \(N(v)\) be the open neighbourhood of \(v\) in \(G\), i.e. the set of all vertices adjacent to \(v\) in \(G\). If \(f\) is a mapping of \(V\) into a number set and \(S\subseteq V\),
openaire +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Computing locating-total domination number in some rotationally symmetric graphs. [PDF]
Sci Prog, 2021 Raza H, Iqbal N, Khan H, Botmart T.
europepmc +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source