Results 91 to 100 of about 368,338 (322)

Maximum Number of Minimum Dominating and Minimum Total Dominating Sets

open access: yes, 2013
Given a connected graph with domination (or total domination) number \gamma>=2, we ask for the maximum number m_\gamma and m_{\gamma,T} of dominating and total dominating sets of size \gamma.
Godbole, Anant   +2 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Signed total domination in graphs

open access: yesDiscrete Mathematics, 2004
The paper continues the study of the signed total domination in graphs which was started by the reviewer. Let \(G\) be a graph with vertex set \(V\). For each \(v\in V\) let \(N(v)\) be the open neighbourhood of \(v\) in \(G\), i.e. the set of all vertices adjacent to \(v\) in \(G\). If \(f\) is a mapping of \(V\) into a number set and \(S\subseteq V\),
openaire   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Augmenting graphs to partition their vertices into a total dominating set and an independent dominating set [PDF]

open access: yesOpuscula Mathematica
A graph \(G\) whose vertex set can be partitioned into a total dominating set and an independent dominating set is called a TI-graph. There exist infinite families of graphs that are not TI-graphs. We define the TI-augmentation number \(\operatorname{ti}(
Teresa W. Haynes, Michael A. Henning
doaj   +1 more source

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