Results 111 to 120 of about 16,582,220 (297)

Synergistic Effect of TID and SEE in 130 nm 7T SOI SRAM

Yuanzineng kexue jishu
The space environment is a very harsh operating environment, and space radiation can directly affect the operation of electronic devices causing total ionizing dose (TID), single event effect (SEE) and displacement damage (DD).
XIAO Shuyan1, GUO Gang1, WANG Linfei2, ZHANG Zheng1, CHEN Qiming1, GAO Linchun2, WANG Chunlin2, ZHANG Fuqiang1, ZHAO Shuyong1, LIU Jiancheng1
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Radiation Effects in p-GaN/AlGaN/GaN HEMTs: A Cross-Source Investigation

IEEE Access
This work presents a comprehensive experimental investigation of radiation effects on p-GaN/AlGaN/GaN high-electron-mobility transistors (HEMTs) under 14 MeV neutrons, 10 keV X-rays, and 1.25 MeV $\gamma $ -rays.
Alexis C. Vilas-Boas, Saulo G. Alberton, Thalia A. Silva, Paulo R. Garcia, Nilberto H. Medina, Vitor A. P. Aguiar, Roberto B. B. Santos, Renato C. Giacomini, Tassio C. Cavalcante, Luis E. Seixas, Saulo Finco, Francisco R. Palomo, Marcilei A. Guazzelli   +12 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

The Effects of Coenzyme Q10 (CoQ10) on Ionizing Radiation- Induced Pancreatic β-Cell Injury

Endocrinology Research and Practice, 2023
Objective: This study investigated the antioxidant effect of coenzyme Q10 on ionizing radiation- induced oxidative damage in pancreatic β-cells. Methods: Twenty-four male rats were assigned to 4 groups.
Filiz Mercantepe, Levent Tümkaya, Tolga Mercantepe, Sema Yılmaz Rakıcı   +3 more
doaj  

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Effects of Bias, Electrical and Thermal Stress on DDR2 Total Ionizing Dose Response [PDF]

, 2012
We investigate whether bias conditions arid electrical and thermal stresses can affect the Total Ionizing Dose response ofDDR2 ...
Casey, M., LaBel, K. A., Chen, D. K., Ladbury, R. L.   +3 more
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Degradation and failure mechanisms of P-GaN HEMTs in single and complex radiation environments

Nuclear Engineering and Technology
In this work, the mechanisms of single-event burnout (SEB) failure and total ionizing dose effect (TID) in P-type gallium nitride gate high electron mobility transistors (P-GaN HEMTs) were investigated based on experiments and simulation.
Yong-chang Sun, Ying Wang, Wan-zhao Cui, Huo-lin Huang, Yan-xing Song, Fei Cao   +5 more
doaj   +1 more source