Results 101 to 110 of about 135,234 (291)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Sequential obtention of blood–brain barrier-permeable non-polar and polar compounds from Salvia officinalis L. and Eucalyptus globulus Labill. with neuroprotective purposes

This study investigates the biorefinery approach to extracting blood–brain barrier (BBB)-permeable compounds from Eucalyptus globulus Labill. and Salvia officinalis L. for neuroprotective purposes.
Ibáñez, Elena, Mannina, Luisa, Cifuentes, Alejandro, Elena Ibáñez, Gloria Domínguez-Rodríguez, Domínguez-Rodríguez, Gloria, Luisa Mannina, Enrico Romano, Alejandro Cifuentes, Romano, Enrico   +9 more
core   +1 more source

Potensi limbah kulit buah Nyirih Xylocarpus granatum sebagai inhibitor tirosinase

Depik Jurnal, 2014
The aim of the present study was to analyse the peel waste of Xylocarpus granatum fruits as potential source of tyrosinase inhibitors. Dried peel samples were ground to yield a powder (simplicia).
Mohamad Gazali, Neviaty P. Zamani, Irmanida Batubara   +2 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

A Lipidomic Analysis Reveals Dynamic Changes of Polar Lipids for Oil Biosynthesis During Cotyledon Development in Perilla frutescens

Plants
Perilla (Perilla frutescens) is an important oilseed crop valued for its rich content of nutraceutical compounds and polyunsaturated fatty acids. While triacylglycerol biosynthesis has been studied, the role of polar lipids during seed development ...
Xiaoxiao Liu, Jiudong Zhang, Weijun Xu, Xichun Du, Deng Yang, Lingling Xu, Shuangyu Zhang, Tianpeng Gao   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

INFRARED ABSORPTION MEASUREMENT OF HCl, HF, AND N_2O AT SYOWA STATION

, 1994
P(論文)Vertical column densities of HCl, HF, and N_2O were observed using the solar infrared absorption method at Syowa Station, to study the chemistry and dynamics of Antarctic ozone depletion.
キタ, カズユキ, OGAWA, Toshihiro, ムラタ, イサオ, IWAGAMI, Naomoto, MURATA, Isao, KITA, Kazuyuki, イワガミ, ナオモト, オガワ, トシヒロ   +7 more
core   +1 more source

Quality control during repeated fryings

Grasas y Aceites, 1998
Most of the debate ¡s about how the slow or frequent turnover of fresh fat affects the deterioration, of fat used in frying. Then, the modification of different oils used in repeated fryings of potatoes without or with turnover of fresh oil, under ...
C. Cuesta, F. J. Sánchez-Muniz
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source