Results 31 to 40 of about 707 (168)

Natural Lipid Extracts as an Artificial Membrane for Drug Permeability Assay: In Vitro and In Silico Characterization

Pharmaceutics, 2023
In vitro non-cellular permeability models such as the parallel artificial membrane permeability assay (PAMPA) are widely applied tools for early-phase drug candidate screening.
Anna Vincze, Gergely Dékány, Richárd Bicsak, András Formanek, Yves Moreau, Gábor Koplányi, Gergely Takács, Gábor Katona, Diána Balogh-Weiser, Ádám Arany, György T. Balogh   +10 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Exploring the phyto- and physicochemical evaluation, fluorescence characteristics, and antioxidant activities of Acacia ferruginea Dc: an endangered medicinal plant

Future Journal of Pharmaceutical Sciences, 2021
Background Herbal plants are potent in curing various ailments of ancient times as they have comparatively lesser side effects. The demands for natural drugs, mostly from plant sources, are increasing over the past few decades.
M. Jeevitha, Pavithra V. Ravi, Vinodhini Subramaniyam, Moorthi Pichumani, Shubashini K. Sripathi   +4 more
doaj   +1 more source

Isolation of a High Antioxidant Non-Toxic Polar Fraction from Garcinia mangostana Fruit Pericarp by Reverse Phase Column Chromatography

Jurnal Kimia Sains dan Aplikasi, 2021
The crude polar extract of mangosteen fruit pericarp not only has a moderate antioxidant activity of (55±4 μg/mL) but also has high cytotoxicity (16±0.5 μg/mL).
Wahyuningsih Wahyuningsih, Miranti Miranti, Hilwan Yuda Teruna, Titania Tjandrawati Nugroho   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Alterações físico-químicas dos óleos de girassol, milho e soja em frituras

Química Nova, 2005
The aim of this study is to determine the influence of frying time on the alterations of sunflower, corn and soybean oils during deep fat frying of potato chips.
Jorge Neuza, Soares Bruno Bellei Prazeres, Lunardi Vanessa Martins, Malacrida Cassia Roberta   +3 more
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Development of a comprehensive approach for the characterization of polar plant decoctions by orthogonal LC-MS reversed phase, HILIC, and NMR metabolite profiling: the case of Combretum micranthum

Frontiers in Natural Products
IntroductionPlant decoctions are especially valued in ethnomedicine for their simplicity, accessibility, and effectiveness in delivering therapeutic compounds.
Lisa Vuadens, Lisa Vuadens, Robin Huber, Robin Huber, Laurence Marcourt, Laurence Marcourt, Luis-Manuel Quiros-Guerrero, Luis-Manuel Quiros-Guerrero, Olivier Auguste Kirchhoffer, Olivier Auguste Kirchhoffer, Arnaud Gaudry, Arnaud Gaudry, Renata Campos Nogueira, Elhadji Assane Diop, Elhadji Assane Diop, Sidi Mohamed Seck, Sidi Mohamed Seck, Jean-Luc Wolfender, Jean-Luc Wolfender, Emerson Ferreira Queiroz, Emerson Ferreira Queiroz   +20 more
doaj   +1 more source

Synergistic Interactions between Tocol and Phenolic Extracts from Different Tree Nut Species against Human Cancer Cell Lines

Molecules, 2022
Tree nuts are rich in polar (phenolic compounds) and non-polar (tocols) antioxidants, with recognized effects in the prevention of diseases such as cancer.
Jazmín C. Stevens-Barrón, Abraham Wall-Medrano, Emilio Álvarez-Parrilla, Imelda Olivas-Armendáriz, Humberto Astiazaran-García, Ramón E. Robles-Zepeda, Laura A. De la Rosa   +6 more
doaj   +1 more source