Results 111 to 120 of about 6,919,485 (295)

Coefficientwise Hankel-total positivity of the Schett polynomials

open access: yes, 2023
LaTeX2e, 12 pages, extended abstract submitted to FPSAC 2024We prove the coefficientwise Hankel-total positivity of the even and odd subsequences of Schett polynomials $X_n(x,y,z)$
Deb, Bishal, Sokal, Alan D.
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Enumerative combinatorics, continued fractions and total positivity [PDF]

open access: yes, 2023
Determining whether a given number is positive is a fundamental question in mathematics. This can sometimes be answered by showing that the number counts some collection of objects, and hence, must be positive.
Deb, Bishal
core  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Current Status on the Epidemiology of Hepatitis B Virus Infection in İstanbul

open access: yesMediterranean Journal of Infection, Microbes and Antimicrobials
Introduction: Despite the availability of safe and effective vaccines against Hepatitis B virus (HBV), the infection remains a significant global health issue.
Mehmet Karabey   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Total positivity of a Cauchy kernel

open access: yesJournal of Approximation Theory, 2014
We study the total positivity of the kernel $1/(x^2 + 2 \cos(π\a)xy +y^2).$ The case of infinite order is characterized by an application of Schoenberg's theorem. We then give necessary conditions for the cases of any given finite order with the help of Chebyshev polynomials of the second kind.
openaire   +4 more sources

Different reactive profiles of calmodulin in the CSF samples of Chinese patients of four types of genetic prion diseases

open access: yesFrontiers in Molecular Neuroscience
Background and purposeCalmodulin (CaM) levels exhibit significant elevation in the brain tissue of rodent and cell line models infected with prion, as well as in the cerebrospinal fluid (CSF) samples from patients diagnosed with sporadic Creutzfeldt ...
Xiao-Xi Jia   +15 more
doaj   +1 more source

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