Results 191 to 200 of about 3,883,670 (317)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A Pilot Investigation of Transforming Growth Factor-β2 and Total Protein Concentrations in Aqueous Humor of Canine Glaucomatous Eyes With and Without Ahmed Glaucoma Valve Surgery. [PDF]

Vet Ophthalmol
Lee S, Seo K, Kang S.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Analyzing the Biochemistry of Saliva: Flow, Total Protein, Amylase Enzymatic Activity, and Their Interconnections. [PDF]

Int J Mol Sci
Parraca JA, Rubio-Zarapuz A, Tornero-Aguilera JF, Clemente-Suárez VJ, Tomas-Carus P, Costa AR.   +5 more
europepmc   +1 more source

Analysis of influencing factors of serum total protein and serum calcium content in plasma donors. [PDF]

PeerJ, 2022
Liu B, Dong D, Wang Z, Gao Y, Yu D, Ye S, Du X, Ma L, Cao H, Liu F, Zhang R, Li C.   +11 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Refractometric methods for determining total protein [PDF]

Biochemical Journal, 1937
openaire   +2 more sources

Enhanced protein extraction and quantification protocol for microsamples: An ultra-sensitive workflow for low-volume, low-concentration total protein lysates. [PDF]

Protein Sci
Wilcox T, Widlansky ME, Westhoff J, Wang J, Ying R, Thorgerson A, Roberts ML.   +6 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Comparative Evaluation of Pleural Fluid Cholesterol and Total Protein Versus Light's Criteria in Differentiation of Exudates and Transudates: A Cross-Sectional Analysis at Tribhuvan University Teaching Hospital. [PDF]

Clin Respir J
Subedi AR, Shrestha TM, Shakya YL, Budha B.   +3 more
europepmc   +1 more source