Results 281 to 290 of about 12,937,378 (338)

Placebo Effect Sizes in Clinical Trials of Knee Osteoarthritis Using Intra‐Articular Injections of Biologic Agents

Arthritis Care &Research, EarlyView.
Objective Patients with knee osteoarthritis rely on symptomatic treatments, in which up to 75% of the pain reduction can be attributed to the placebo effect. This effect may vary based on treatment type (eg, biologics vs nonbiologic injection) and route of administration (eg, intra‐articular vs topical vs oral).
Johanna M. Borst, Severin Ruoss, Ian Palmer, Trevor Smith, Kenneth Kalunian, Samuel R. Ward   +5 more
wiley   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Ageism in Rheumatology: the Healthcare Professional's Perspective

Arthritis Care &Research, Accepted Article.
Objective Ageism (age‐based stereotypes, prejudice, or discrimination) is prevalent and linked to prolonged disability and reduced lifespan in older adults. Little is known about ageism within rheumatology. This study explores the healthcare professional's (HCP) perception of the care of older adults and how ageist attitudes or perspectives may impact ...
Aaron P. Smith, Pooja M. Achanta, Jiha Lee, Namrata Singh, Una E. Makris   +4 more
wiley   +1 more source

Moderators and mediators of pain and function outcomes in a new service delivery model for management of knee osteoarthritis in primary care (PARTNER): Secondary exploratory analysis of a randomized controlled trial

Arthritis Care &Research, Accepted Article.
Objective Explore moderators and mediators influenced changes in pain and function in people with knee osteoarthritis (OA) receiving a new model of primary care service delivery (PARTNER), at 12 months (ACTRN12617001595303). Methods Secondary analyses of a cluster randomized controlled trial comparing PARTNER to usual general practitioner‐delivered ...
Abdolhay Farivar, Jocelyn L Bowden, Kim L Bennell, Andrew M Briggs, Stephen J Bunker, Rana S Hinman, Thorlene Egerton, Simon D French, Marie Pirotta, Karen Schuck, Venkatesha Venkatesha, Nicholas A Zwar, David J Hunter   +12 more
wiley   +1 more source

Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis

Advanced Biology, EarlyView.
Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard, Kaja Borup Løvschall, Mireia Casanovas Montasell, Clara Bakkegaard Cramer, Pere Monge Marcet, Andreas Bøtker Pedersen, Josefine Hammer Jakobsen, Alexander N. Zelikin   +7 more
wiley   +1 more source

Elucidating the Supramolecular Interaction of Positively Supercharged Fluorescent Protein with Anionic Phthalocyanines

Advanced Biology, EarlyView.
Positively supercharged mGreenLatern protein is self‐assembled electrostatically with negatively charged zinc phthalocyanines to yield bio‐based photoactive materials in aqueous media. The addition of phthalocyanines results in the formation of large complexes fully quenching of the protein fluorescence. The results indicate an energy transfer from the
Sharon Saarinen, Ramsha Khan, Marta Patrian, Juan Pablo Fuenzalida‐Werner, Rubén D. Costa, Petr Zimcik, Veronika Novakova, Tero‐Petri Ruoko, Nikolai V. Tkachenko, Eduardo Anaya‐Plaza, Mauri A. Kostiainen   +10 more
wiley   +1 more source

Correction: Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone

Beilstein Journal of Organic Chemistry
Ilya A. P. Jourjine, Lukas Zeisel, Jürgen Krauß, Franz Bracher   +3 more
doaj   +1 more source

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Total Synthesis of Darobactin A.

Journal of the American Chemical Society, 2022
The collaborative total synthesis of darobactin A, a recently isolated antibiotic that selectively targets Gram-negative bacteria, has been accomplished in a convergent fashion with a longest linear sequence of 16 steps from d-Garner's aldehyde and l ...
M. Nešić, David B. Ryffel, Jonathan Maturano, M. Shevlin, Scott R Pollack, D. Gauthier, Pablo Trigo-Mourino, Li-Kang Zhang, Danielle M. Schultz, Jamie M McCabe Dunn, Louis-Charles Campeau, Niki R. Patel, David A Petrone, D. Sarlah   +13 more
semanticscholar   +1 more source

Asymmetric Total Synthesis of Taxol.

Journal of the American Chemical Society, 2021
Taxol is one of the most famous natural diterpenoids and an important anticancer medicine. Taxol represents a formidable synthetic challenge and has prompted significant interest from the synthetic community.
Ya-Jian Hu, Chengyun Gu, Xin-Feng Wang, Long Min, Chuang-Chuang Li   +4 more
semanticscholar   +1 more source

Construction of sulfur-containing moieties in the total synthesis of natural products.

Natural product reports (Print), 2020
Covering: January 2013 to September 2018Sulfur-containing natural products are a large class of significant functional molecules. Many of these compounds exhibit potent biological activities and pharmacological properties; in fact, some of them have been
Nengzhong Wang, Puli Saidhareddy, Xuefeng Jiang   +2 more
semanticscholar   +1 more source