Results 291 to 300 of about 16,454,265 (355)

Total Synthesis of (+)-Astrophylline

The Journal of Organic Chemistry, 2003
The first total synthesis of (+)-astrophylline (2) has been achieved, starting from readily available enantiomerically pure (+)-(1R,4S)-4-hydroxycyclopent-2-enyl acetate (11). A novel ruthenium-catalyzed ring-closing ring-opening ring-closing metathesis of carbocyclic olefins of general type 5 was the key step, providing the stereochemically well ...
Marco, Schaudt, Siegfried, Blechert
openaire   +2 more sources

Total synthesis of bryostatin 3

Science, 2020
Stitching alkynes into bryostatin 3 The bryostatin family of marine natural products has been explored for a wide variety of pharmaceutical applications but remains challenging to source.
B. Trost, Youliang Wang, A. Buckl, Zhongxing Huang, M. Nguyen, O. Kuzmina   +5 more
semanticscholar   +1 more source

Total synthesis of amurine

Tetrahedron Letters, 1968
The diazotisation of 6,7-dimethoxy- and 7-ethoxy-6-methoxy-1-(2-amino-4,5-methylenedioxybenzyl)-1,2,3,4-tetrahydro-2-methylisoquinoline (XII) and (XV), followed by thermal decomposition, gave amurine (Ib), as a result of which Dopke's structure for the alkaloid was proved to be correct.
T, Kametani, K, Fukumoto, T, Sugahara
openaire   +2 more sources

Total Synthesis of (‐)‐Gambierol.

ChemInform, 2002
The first total synthesis of (-)-gambierol (1), a marine polycyclic ether toxin, has been achieved. Key features of the successful synthesis include (1) a convergent union of the ABC and EFGH ring fragments (5 and 6, respectively) via our developed B-alkyl Suzuki-Miyaura cross-coupling strategy leading to the octacyclic polyether core 4 and (2) a late ...
Haruhiko, Fuwa, Noriko, Kainuma, Kazuo, Tachibana, Makoto, Sasaki   +3 more
openaire   +2 more sources

Total Synthesis of (±)‐Strictamine

Angewandte Chemie International Edition, 2016
AbstractThe total synthesis of strictamine has been achieved in nine steps from a known enol triflate. Characteristic features of our approach included: a) creation of a C7 all‐carbon quaternary stereocenter at an early synthetic stage; b) use of an N,N‐dimethyl tertiary amine as a surrogate of the primary amine for the rapid build‐up of a ...
Weiwu, Ren, Qian, Wang, Jieping, Zhu
openaire   +2 more sources

"Macho Total Synthesis"

Science, 1999
Robert F. Service (News Focus, 9 July, p. [184][1]) has written an insightful critique of what insiders call “macho total synthesis,” in which huge teams (20 to 30 postdocs and graduate students representing a critical mass) race to be the first to accomplish the synthesis of extremely complex natural products.
openaire   +2 more sources

Total Synthesis of (+)-Muconin

The Journal of Organic Chemistry, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Takehiko, Yoshimitsu, Toshiyuki, Makino, Hiroto, Nagaoka   +2 more
openaire   +2 more sources

Enantioselective Total Synthesis of (-)-Arcutinine.

Journal of the American Chemical Society, 2019
The first total synthesis of an arcutine-type C20-diterpenoid alkaloid arcutinine has been achieved in both racemic and asymmetric forms. Construction of the C4 quaternary center and the pyrrolidine E ring in an early stage proved to be important for ...
W. Nie, Jing Gong, Zhihao Chen, Jiazhen Liu, Di Tian, Hao Song, Xiao‐Yu Liu, Yong Qin   +7 more
semanticscholar   +1 more source

Total Synthesis of (‐)‐Cassine.

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Hidefumi, Makabe, Looi Kok, Kong, Mitsuru, Hirota   +2 more
openaire   +2 more sources

Total Synthesis of (-)-Daphenylline.

Angewandte Chemie, 2019
A concise and highly stereoselective total synthesis of the Daphniphyllum alkaloids (-)-daphenylline has been accomplished. The synthesis was started from (S)-carvone and proceeded via a stereoselective Mg(ClO4 )2 -catalyzed intramolecular amide addition
Bo Xu, Bingyang Wang, Wen Xun, Fayang G. Qiu   +3 more
semanticscholar   +1 more source