Results 291 to 300 of about 3,850,300 (360)

Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues. [PDF]

Angew Chem Int Ed Engl
George MRP, Elsadek LA, Deering M, de Almeida LC, Tyler JL, Noble A, Paul VJ, Luesch H, Butts CP, Aggarwal VK.   +9 more
europepmc   +1 more source

Total synthesis of the antibiotic WS-5995A using a key reaction of o-toluamide anions with homophthalic anhydrides.

, 1989
Mitsuaki Watanabe, M. DATE, S. FURUKAWA
openalex   +2 more sources

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

A Divergent Asymmetric Total Synthesis of Coprophilin and Four Trichodermic Acids via a [1,5]-Hydride Shift-Aldol Cascade. [PDF]

J Am Chem Soc
Smith E, Jenkins TC, Yeung CS, Donohoe TJ.   +3 more
europepmc   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Isolation, Total Synthesis and Anti-Diabetic Activity of Filiforidine from <i>Cassytha filiformis</i>. [PDF]

Molecules
Zhang C, Zhu H, Zhang F, Jiang Y, Huang Z, Lin D, Chen N, Zhang X, Fu Y.   +8 more
europepmc   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Total Synthesis of (-)-Neocucurbol C Enabled by Pattern Recognition and MHAT Cyclization. [PDF]

J Am Chem Soc
Zhong LP, Gudeman C, Zhen J, Wanasinghe OA, Hellmig J, Collins MJE, Bacsa J, Adibekian A, Dai M.   +8 more
europepmc   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Total Synthesis of Feglymycin Using Umpolung Amide Synthesis. [PDF]

Angew Chem Int Ed Engl
Gourville PC, Bing JA, Quarels RD, Tsukanov SV, Schwieter KE, Tokumaru K, Stephens AB, Makley DM, Shen B, Smith AN, Johnston JN.   +10 more
europepmc   +1 more source