Results 321 to 330 of about 14,944,148 (406)

Divergent Enantioselective Total Synthesis of (-)-Ajmalicine, (+)-Mayumbine, and (-)-Roxburghine C. [PDF]

Org Lett
Goëlo V, Wang Q, Zhu J.
europepmc   +1 more source

Domain Specific Placebo Response in the Modified Friedreich's Ataxia Rating Scale

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The placebo response in clinical trials in ataxias complicates outcome interpretation and potentially obscures genuine treatment effects. We analyzed placebo group data from past trials in Friedreich Ataxia and observed notable responses in appendicular items, in contrast to minimal changes in axial function, as measured by respective ...
Christian Rummey, Jennifer M. Farmer, David R. Lynch   +2 more
wiley   +1 more source

Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring comprehensive medical and supportive care.
Amin Mehrabian, Peter Auguste, Amy Grove, Anna Brown, Janette Parr, Mubarak Patel, Furqan Butt, Jeremiah Donoghue, Mehdi Yousefi, Jo Parsons   +9 more
wiley   +1 more source

Effect of Nonsteroidal Anti‐Inflammatory Drugs on Sacroiliac Joint Inflammation, as Seen on Magnetic Resonance Imaging, in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Objective Imaging evidence of active sacroiliitis is important for diagnosis, classification, and monitoring of axial spondyloarthritis (axSpA). However, there is no consistent guidance on whether patients should temporarily stop nonsteroidal anti‐inflammatory drugs (NSAIDs) before magnetic resonance imaging (MRI).
Gareth T. Jones, Alexander N. Bennett, Raj Sengupta, Pedro M. Machado, Helena Marzo‐Ortega, Lorna Aucott, Margaret A. Hall‐Craggs, Timothy J. P. Bray, Alan Bainbridge, Ruaridh M. Gollifer, Gary J. Macfarlane   +10 more
wiley   +1 more source

Beyond Neuroprostanes: Total Synthesis and Epilipidomic Studies of a Novel Cyclopentenone Metabolite of Docosahexaenoic Acid. [PDF]

Chemistry
Pavlíčková T, Bultel-Poncé V, Roy J, Reversat G, Vigor C, Durand T, Jahn U, Galano JM, Oger C.   +8 more
europepmc   +1 more source

Asymmetric Total Synthesis and Structural Reassignment of Nervione. [PDF]

J Org Chem
Phakdeeyothin K, Li JL, Hong YT, Chein RJ.   +3 more
europepmc   +1 more source

The application of desymmetric enantioselective reduction of cyclic 1,3-dicarbonyl compounds in the total synthesis of terpenoid and alkaloid natural products. [PDF]

Beilstein J Org Chem
Tan DX, Han FS.
europepmc   +1 more source

Ligand Type Guided Keto-Arylation Enables Modular Total Synthesis of Polycyclic CBS Xanthones. [PDF]

Angew Chem Int Ed Engl
Meringdal JW, Prangenberg V, Treiber T, Schneider AJ, Honsdorf L, Menche D.   +5 more
europepmc   +1 more source

Asymmetric total synthesis of tricyclic prostaglandin D2 metabolite methyl ester via oxidative radical cyclization. [PDF]

Beilstein J Org Chem
Xiao M, Pu L, Shang Q, Zhu L, Huang J.
europepmc   +1 more source

Azine Dearomatization in Natural Product Total Synthesis. [PDF]

Chemistry
Knight BJ, Grigolo TA, Tolchin ZA, Smith JM.   +3 more
europepmc   +1 more source