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Total Synthesis of Darobactin A.
Journal of the American Chemical Society, 2022The collaborative total synthesis of darobactin A, a recently isolated antibiotic that selectively targets Gram-negative bacteria, has been accomplished in a convergent fashion with a longest linear sequence of 16 steps from d-Garner's aldehyde and l ...
M. Nešić +13 more
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Asymmetric Total Synthesis of Taxol.
Journal of the American Chemical Society, 2021Taxol is one of the most famous natural diterpenoids and an important anticancer medicine. Taxol represents a formidable synthetic challenge and has prompted significant interest from the synthetic community.
Ya-Jian Hu +4 more
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Time and Pot Economy in Total Synthesis.
Accounts of Chemical Research, 2021ConspectusWe would all like to make or obtain the materials or products we want as soon as possible. This is human nature. This is true also for chemists in the synthesis of organic molecules.
Y. Hayashi
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Construction of sulfur-containing moieties in the total synthesis of natural products.
Natural product reports (Print), 2020Covering: January 2013 to September 2018Sulfur-containing natural products are a large class of significant functional molecules. Many of these compounds exhibit potent biological activities and pharmacological properties; in fact, some of them have been
Nengzhong Wang +2 more
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Time Economy in Total Synthesis.
Journal of Organic Chemistry, 2020It is often said that "time is money". This is certainly true in a multistep synthesis when a high-valued product or set of products is needed urgently. Fulfilling this need requires the sensible balancing of atom economy, step economy, and redox economy
Y. Hayashi
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Modular Total Synthesis in Reticular Chemistry.
Journal of the American Chemical Society, 2020The idea of modularity in organic total synthesis has promoted the construction of diverse targeted natural products by varying the building blocks and assembly sequences.
Liang Feng +5 more
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