Results 81 to 90 of about 7,929 (288)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

_Ressentiment_, the Superego, and Totalitarianism [PDF]

open access: yes, 2003
draws from Nietzsche, Freud, Camus, Arendt, Lacan, and Lefort to analyze ...
Cheng, Sinkwan
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

THE ANATOMY OF POST-TOTALITARIANISM.

open access: yes, 2019
Celem niniejszego artykułu jest krytyczna analiza głównych tez książki Aviezera Tuckera The Legacies of Totalitarianism. A Theoretical Framework.
Michał Kwiecień, Michał Kwiecień
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Modern Dystopias and Theories of Totalitarianism [PDF]

open access: yes, 2013
The diploma thesis Modern Dystopias and Theories of Totalitarianism deals with comparation of this two phenomena. The thesis is based on the concept of Giovanni Sartori.
Machart, Filip
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

BOOK REVIEW: Peter Bernholz, ‟Totalitarianism, Terrorism and Supreme Values. History and Theory Cham”, Springer, 2017, 160 pp.

open access: yesStudia Universitatis Babeş-Bolyai. Studia Europaea, 2019
The book written by Peter Bernholz represents the culmination of a process, serving to refine his theory on the lexicographic preference for supreme values and its fundamental role in the ideologies of totalitarian regimes. As the author mentions in the
Mihai MURARIU
doaj  

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