Results 111 to 120 of about 16,960 (297)

In-vitro studies of Toxic Shock Toxin-1 secreting Staphylococcus aureus and implications for burn care in children

, 2012
Background: The main etiologic agent of toxic shock syndrome is the toxic shock syndrome toxin-1 (TSST-1) protein secreted by Staphylococcus aureus. Diagnosis of toxic shock syndrome is difficult and is significantly underdiagnosed in young children with
Young, Amber, Laabei, Maisem, Jenkins, A Toby A   +2 more
core   +1 more source

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

Imbalanced serum IgG subclass pattern in toxic shock syndrome patients: deficiency of specific IgG1 and IgG4 subclass antibodies to toxic shock syndrome toxin 1

, 1986
An imbalanced serum IgG subclass pattern was identified in 10 patients with toxic shock syndrome (TSS) showing remarkably low subclass levels of various combinations. IgG2 levels were significantly reduced as compared to normal controls. The IgG subclass-
Christensson, B, Johansson, Hugo, Oxelius, Vivi-Anne   +2 more
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Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

The Isolation and Detection of Staphylococcus aureus Enterotoxins A-E and TSST-1 Genes from Different Sources by PCR Method

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2012
Background and Objectives: Enterotoxins and toxic shock syndrome toxin–1 (TSST-1) are an important virulence factor of S. aureus. The purpose of this study was to analyze the presence of S.
Norouzi J, Goudarzi G, Pakzad P, Razavipour R   +3 more
doaj   +2 more sources

Toxin production and drug resistance profiles of pediatric methicillin-resistant Staphylococcus aureus isolates in Tehran

Journal of Infection in Developing Countries, 2017
Introduction: Staphylococcus aureus is known to be a major cause of skin and soft tissue infections, pneumonia and invasive diseases. In this study, attempts were made to examine the prevalence of tsst-1, eta, etb, and luk-PV genes among methicillin ...
Mozhgan Esmaeili Benvidi, Hamidreza Houri, Zohreh Ghalavand, Bahram Nikmanesh, Hadi Azimi, Roghayeh Samadi, Narges Nodeh Farahani, Gita Eslami   +7 more
doaj   +1 more source

Detection of antibodies to Staphylococcus aureus Toxic Shock Syndrome Toxin-1 using a competitive agglutination inhibition assay

, 2003
Aims:To develop a competitive agglutination inhibition assay (CAIA) for the detection of anti-Toxic Shock Syndrome Toxin-1 (TSST-1) antibody in serum samples using a commercially available reverse passive agglutination assay (RPLA) kit.
Foster, Howard A., Edwards-Jones, Valerie, Khojasteh, V. Javid, Rogan, Michael T.   +3 more
core   +1 more source

Early prediction of multiple organ failure for sepsis patients based on machine learning algorithms

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, there has been a notable rise in sepsis incidence leading to more multiple organ failure and higher mortality. The lack of effective treatments for sepsis highlights the importance of early prediction in preventing multiple organ failure. This study aimed to develop a model for the early prediction of multiple organ failure in
Runnan He, Nan Su, Yuqing Wang, Yulin Sun, Xin Weng, Tania Pereira, Chenggong Hu, Keliang Xie, Meijun Pang, Kuo Zhang, Chuanxiang Huang, Xiuyun Liu   +11 more
wiley   +1 more source

Peppermint Oil Decreases the Production of Virulence-Associated Exoproteins by Staphylococcus aureus

Molecules, 2011
The present study aimed to evaluate the antimicrobial activity of peppermint oil against Staphylococcus aureus, and further investigate the influence of peppermint oil on S. aureus virulence-related exoprotein production.
Xu-Ming Deng, Wen-Zhi Ren, Bing-Feng Leng, Ming-Jing Luo, Hong-En Li, Jian-Feng Wang, Jing Dong, Jia-Zhang Qiu, Jing Li   +8 more
doaj   +1 more source

Screening and application of aptamers to Staphylococcus aureus Toxic Shock Syndrome Toxin-1 [PDF]

, 2016
摘要 目的：金黄色葡萄球菌(Staphylococcusaureus)分泌的毒性休克综合征毒素-1(ToxicShockSyndromeToxin-1，TSST-1)引发中毒性休克综合征(ToxicShockSyndrome，TSS)，通过激活T淋巴细胞使其活化、增殖，引起强烈的免疫应答。目前针对TSST-1本身的治疗手段不多，合成寡核苷酸文库和亲和力筛选作为获得高亲和力、高特异性适配体(Aptamer)的一种方便、快捷、有效的方法。本研究利用指数富集的配体系统进化技术 ...
陈弘炜
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