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Toxic Shock Syndrome Toxin 1 Is Encoded by a Variable Genetic Element
Clinical Infectious Diseases, 1989The primary cause of toxic shock syndrome is toxic shock syndrome toxin 1 (TSST-1), a 22,049-dalton exotoxin. Approximately 20% of Staphylococcus aureus isolates produce TSST-1; the production of this toxin is therefore a variable genetic trait. The TSST-1 gene and its flanking sequences are found on a genetic element that is present in TSST-1-positive
B N, Kreiswirth +3 more
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The role of toxic shock syndrome toxin-1 in the pathogenesis of toxic shock syndrome
2010Toxic shock syndrome toxin-1 (TSST-1), an exoprotein produced by some strains of Staphylococcus aureus, is implicated in the pathogenesis of menstrual TSS. However, its role in nonmenstrual TSS is less certain. In order to study the pathogenetic role of TSST-1 in TSS, three approaches were taken: a) to develop an ELISA for detection of TSST-1 in ...
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Toxic Shock Syndrome Toxin 1 Contributes to the Arthritogenicity of Staphylococcus aureus
Journal of Infectious Diseases, 1994Although enterotoxins have been implicated in disease states such as food poisoning and toxic shock syndrome, their role in infectious arthritis is not known. To study the arthritogenic properties of toxic shock syndrome toxin 1 (TSST-1), two pairs of S.
A, Abdelnour, T, Bremell, A, Tarkowski
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Separation of Function Between the Domains of Toxic Shock Syndrome Toxin-1
The Journal of Immunology, 1998Abstract Toxic shock syndrome toxin-1 (TSST1) is a superantigenic exotoxin produced by certain strains of Staphylococcus aureus. Structurally, TSST1 is composed of two domains: residues determined by crystallography to directly interact with MHC II molecules reside within the N-terminal domain, while TSST1 residues critical for ...
J L, Wahlsten, S, Ramakrishnan
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Toxic shock syndrome toxin-1-induced death is prevented by CTLA4Ig
The Journal of Immunology, 1996Abstract Lethal toxic shock syndrome (TSS) results from the MHC class II presentation of bacterial superantigens, most commonly toxic shock syndrome-1 (TSST-1), to specific TCR Vbeta-bearing T cells. This superantigen-induced stimulation of whole T cell subsets leads to the exuberant cytokine production that in turn causes the shock ...
B, Saha +5 more
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Effect of Tampon Wraps on Production of Toxic Shock Syndrome Toxin 1
Clinical Infectious Diseases, 1989The influence of tampon wraps on the production and distribution of toxic shock syndrome toxin 1 (TSST-1) was investigated with use of a disk-membrane-agar method. Filter membranes (45 micron) overlaying agar medium in 50-mm petri dishes were spread-inoculated with a TSST-1-producing strain of Staphylococcus aureus and covered with 0.5 mL of whole ...
R N, Robbins +3 more
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Effect of Magnesium on in Vitro Production of Toxic Shock Syndrome Toxin 1
Clinical Infectious Diseases, 1989Batch and chemostat culture of Staphylococcus aureus strain S411 was conducted in an investigation of the role of Mg++ in the control of production of toxic shock syndrome toxin 1 (TSST-1). Under both growth conditions, Mg++ influenced bacterial growth, and TSST-1 production was correlated with bacterial growth.
J F, James +7 more
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Effect of toxic shock syndrome toxin-1 on human hemostatic parameters
Thrombosis Research, 1989The effect of toxic-shock-syndrome-toxin-1 (TSST-1) on coagulation and platelet aggregation was studied in blood samples from human healthy volunteers. TSST-1 at 5 micrograms/ml does not modify the extrinsic or intrinsic coagulation pathways. However, thrombin clotting time (TCT) was significantly increased in the presence of TSST-1.
R, Gareau, J, Gruda, V V, Micusan
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Staphylococcal toxic shock syndrome toxin-1 inhibits monocyte apoptosis
Journal of Allergy and Clinical Immunology, 1999Chronic atopic dermatitis (AD) lesions are associated with colonization by exotoxin-producing Staphylococcus aureus. Evidence suggests that cytokine production in AD, particularly of GM-CSF, prolongs survival of both peripheral blood monocytes and dermal monocyte-macrophages, the predominate inflammatory cell in lesions caused by chronic AD.We sought ...
D L, Bratton +4 more
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Growth and analysis of crystal forms of toxic shock syndrome toxin 1
Proteins: Structure, Function, and Bioinformatics, 1993AbstractNative toxic shock syndrom toxin 1 (TSST‐1) purified from Staphylococcus aurius has been crystallized in four different forms. The highest resolution data (2.05 Å) was collected from orthorhombic crystals belonging to the space group C2221. The unit cell dimension are a = 108.7 Å, b = 177.5 Å, c = 97.6 Å. Rotation function analysis of this from
C A, Earhart +5 more
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