Results 101 to 110 of about 2,863,474 (344)

Generation of hereditary spastic paraplegia patient-derived induced pluripotent stem cell line UJSi003-A

Stem Cell Research
Hereditary spastic paraplegia (HSP) is a rare neurodegenerative disorder with the predominant clinical manifestation of spasticity in the lower extremities.
Tingkai Sun, Bonan Chen, Dingqi Zhang, Xuan Xu, Jing Gao, Jing Sun, Muyun Wei   +6 more
doaj   +1 more source

Chronic toxicity of inhaled thymol in lungs and respiratory tracts in mouse model. [PDF]

, 2019
Epinephrine HFA (Primatene® Mist) is a newly formulated asthma metered dose inhaler developed to replace the previous Primatene® Mist CFC. The formulation of Epinephrine HFA contains thymol, a substance recognized to be safe by the FDA.
Luo, Mary Z, Tashkin, Donald P, Xie, Kevin, Zhang, Jack Y   +3 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. [PDF]

, 2014
Activating mutations in FLT3 confer poor prognosis for individuals with acute myeloid leukemia (AML). Clinically active investigational FLT3 inhibitors can achieve complete remissions but their utility has been hampered by acquired resistance and ...
He, Bai-Liang, He, Bai-Liang, Lasater, Elisabeth A, Leung, Anskar Yh, Lin, Kimberly, Lopez, Michael S, Shah, Neil P, Shokat, Kevan M, Smith, Catherine C, Warkentin, Alexander A   +9 more
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Generation of induced pluripotent stem cell line UJSi005-A from developmentally delayed schizophrenic patients

Stem Cell Research
Schizophrenia, a chronic mental health condition, is characterized by abnormalities in perception, emotions and behavior. We successfully generated induced pluripotent stem cells (iPSCs) from the peripheral blood mononuclear cells (PBMCs) of a patient ...
Xuan Xu, Bing Xue, Dingqi Zhang, Yupeng Wang, Bonan Chen, Zhenghua Shan, Wenzhuo Zhao, Tianxiao Qiu, Jing Sun, Shengying Qin   +9 more
doaj   +1 more source

Interactions between Magnetic Nanowires and Living Cells : Uptake, Toxicity and Degradation

, 2011
We report on the uptake, toxicity and degradation of magnetic nanowires by NIH/3T3 mouse fibroblasts. Magnetic nanowires of diameters 200 nm and lengths comprised between 1 {\mu}m and 40 {\mu}m are fabricated by controlled assembly of iron oxide ({\gamma}
Armelle Baeza-Squiban, Auffan M., Berret J.-F., Brunner T. J., Cappallo N., Champion J. A., Chanteau B., Conner S. D., Denizot F., Dietrich Averbeck, Donaldson K., Doshi N., Dumortier H., Florence Niedergang, Fresnais J., Fresnais J., Fresnais J., Fung A. O., Goubault C., Gratton S. E. A., Hallstrom W., Hillaireau H., Hultgren A., Hurst S. J., Hussain S., Hélène Conjeaud, Jacquin M., Jean-François Berret, Johansson F., Kagan V. E., Kim J., Kuimova M. K., Leung K. C. F., Lewinski N., Lutz J.-F. o., Malak Safi, Marie-Alice Guedeau-Boudeville, Massart R., Minhao Yan, Nan A. J., Nicole Boggetto, Niedergang F., Petri-Fink A., Pisanic T. R., Rad A. M., Safi M., Sehgal A., Singh H., Singh N., Song M. M., Tanase M., Virginie Garnier-Thibaud   +51 more
core   +3 more sources

Subchronic oral toxicity of silver nanoparticles [PDF]

, 2010
Yong Soon Kim, Moon Yong Song, Jung Duck Park, Kyung Seuk Song, Hyeon Ryol Ryu, Yong Hyun Chung, Hee Kyung Chang, Ji Hyun Lee, Kyung Hui Oh, Bruce J. Kelman, In Koo Hwang, Il Je Yu   +11 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source