Telomerase reactivation is responsible for telomere preservation in about 90% of cancers, providing cancer cells an indefinite proliferating potential.
Eric Nguyen +4 more
doaj +1 more source
Evaluation of mutagenicity of zinc oxide nanoparticles by Pig-a mutation assay in vivo
ObjectiveThe genotoxicity of zinc oxide nanoparticles (ZnO NPs) in rats was determined by Pig⁃a mutation assay in vivo.MethodsCombined with 28-day oral toxicity test, male SD rats were given ZnO NPs by oral administration for 28 days, at doses of 0, 14 ...
CHENG Xueqing +4 more
doaj +1 more source
Acute and Subchronic Inhalation Toxicity of n-Octane in Rats
Objectives: We have investigated the toxic effects of the inhalation of subchronic and acute levels of n-octane. Methods: The rats were exposed to n-octane of 0, 2.34, 11.68 and 23.36 mg/L (n = 5 rats/group/gender) in an acute inhalation test ...
Jae Hyuck Sung +8 more
doaj +1 more source
Developmental Toxic Effects of Thiram on Developing Zebrafish (Danio rerio) Embryos
Thiram, an oxidized dimer of dithiocarbamate, has fungicidal and ectoparasiticidal roles. This study aimed to determine the effects of thiram on the development of zebrafish (ZF) embryos.
Bala Murali Krishna Vasamsetti +5 more
doaj +1 more source
Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [PDF]
Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity.
Brown, R. +7 more
core +1 more source
Poison Frog Colors Are Honest Signals Of Toxicity, Particularly For Bird Predators [PDF]
Antipredator defenses and warning signals typically evolve in concert. However, the extensive variation across taxa in both these components of predator deterrence and the relationship between them are poorly understood.
Cummings, Molly E., Maan, Martine E.
core +3 more sources
Toxicity of Pb and of Pb/Cd combination on the springtail Folsomia candida in natural soils: Reproduction, growth and bioaccumulation as indicators [PDF]
The toxicity of Pb and Cd+Pb was assessed on the Collembola F. candida in two cultivated soils (SV and AU) with low organic matter (OM) content and circumneutral to basic pH, and an acid forested soil (EPC) with high OM content.
Bianco, Audrey +4 more
core +2 more sources
Acute toxicity of synyhetic resin effluent to African Catfish, Clarias gariepinus [BURCHELL, 1822]. [PDF]
Aquatic pollution as a field has gained a lot of attention over the decades majorly because of the vital role the aquatic environment plays in the human lifecycle.
Dahunsi, S. O., Oranusi, S. U.
core +1 more source
The skin sensitization potential of agrochemicals can be assessed using laboratory methods such as the keratinocyte activation assay so that their use in regulatory toxicology might replace experimental animal testing.
Ji-Yeon Yang +6 more
doaj +1 more source
Clinical results after high-dose intensity-modulated radiotherapy for high-risk prostate cancer [PDF]
Purpose. Patients with high-risk prostate cancer (PC) can be treated with high-dose intensity-modulated radiotherapy (IMRT) and long-term androgen deprivation (AD).
FONTEYNE, VALERIE +4 more
core +2 more sources

