Results 51 to 60 of about 1,765,392 (245)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Application of bovine corneal opacity and permeability test in the eye irritation evaluation of cosmetics

Shanghai yufang yixue, 2022
ObjectiveTo establish bovine corneal opacity and permeability （BCOP） test， and determine its predictive ability for the eye irritation evaluation of cosmetics.MethodsA total of ten reference chemicals were selected to establish the BCOP test.
HUO Qian, SHA Yijie, XIAO Ping, HONG Xinyu, WANG Letian, ZHENG Weidong, WEI Qi, DONG Cheng, TAO Gonghua   +8 more
doaj   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Head-specific transcriptomic profiles associated with chronic exposure to lambda-cyhalothrin and spinetoram during larval stage in honey bees (Apis mellifera)

Applied Biological Chemistry
Pesticide exposure during larval development can cause long-lasting impairments in honey bees; however, the underlying molecular mechanisms remain unclear.
Bala Murali Krishna Vasamsetti, Hyunjun Lee, Kyongmi Chon, Juyeong Kim, Bo-Seon Kim, Chang-Young Yoon, Sojeong Hwang, Minju Choi, Hui-Yeon Ahn, Kyeong-Hun Park   +9 more
doaj   +1 more source

Synthesis, DFT Study, and In Vitro Evaluation of Antioxidant Properties and Cytotoxic and Cytoprotective Effects of New Hydrazones on SH-SY5Y Neuroblastoma Cell Lines

Pharmaceuticals, 2023
A series of ten new hydrazide–hydrazone derivatives bearing a pyrrole ring were synthesized and structurally elucidated through appropriate spectral characteristics. The target hydrazones were assessed for radical scavenging activity through 1,1-diphenyl-
Diana Tzankova, Hristina Kuteva, Emilio Mateev, Denitsa Stefanova, Alime Dzhemadan, Yordan Yordanov, Alexandrina Mateeva, Virginia Tzankova, Magdalena Kondeva-Burdina, Alexander Zlatkov, Maya Georgieva   +10 more
doaj   +1 more source

Life cycle assessment of biosolids land application and evaluation of the factors impacting human toxicity through plants uptake [PDF]

, 2010
Due to the increasing environmental concerns in the wastewater treatment sector, the environmental impacts of organic waste disposal procedures require careful evaluation. However, the impacts related to the return of organic matter to agricultural soils
Ademe, Basta, Cai, Casado-Vela, Clarke, Epstein, Eriksson, Fava, Gerba, Godfree, Guinée, Hong, Houillon, Huijbregts, Lundin, Mallard, Moss, OTV, Overcash, Reinhardt, Singh, Smith, Spinosa, Suh, US EPA (US Environmental Protection Agency), Wei   +25 more
core   +3 more sources

Aflatoxins: History, Significant Milestones, Recent Data on Their Toxicity and Ways to Mitigation [PDF]

, 2021
Darina Pickova, Vladimír Ostrý, Jakub Toman, František Malíř   +3 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

An EMT-related genes signature as a prognostic biomarker for patients with endometrial cancer

BMC Cancer, 2023
Background The epithelial-mesenchymal transition (EMT) plays an indispensable role in the development and progression of Endometrial cancer (EC). Nevertheless, little evidence is reported to uncover the functionality and application of EMT-related ...
Yonghui Yu, Yiwen Zhang, Zhi Li, Yongshun Dong, Hongmei Huang, Binyao Yang, Eryong Zhao, Yongxiu Chen, Lei Yang, Jiachun Lu, Fuman Qiu   +10 more
doaj   +1 more source

Severe cytokine release syndrome is associated with hematologic toxicity following CD19 CAR T-cell therapy [PDF]

, 2021
Krishna R. Juluri, Qian Wu, Jenna Voutsinas, Jue Hou, Alexandre V. Hirayama, Erin Mullane, Nancy Miles, David G. Maloney, Cameron J. Turtle, Merav Bar, Jordan Gauthier   +10 more
openalex   +1 more source