Results 81 to 90 of about 742,766 (263)

A Novel Approach to Developing Thresholds for Total Dissolved Solids Using Standardized and Experimental Toxicity Test Methods. [PDF]

Environ Toxicol Chem, 2022
Brent RN, Kunkel J, Tomek Z, Buchardt D, DeLisle PF, Sivers S.   +5 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Safe Dosage of Caprine CSN1S2 Protein from Fresh Local Goat Milk for Rats Evaluated by Acute and Sub-Chronic Toxicity Testing

Journal of Mathematical and Fundamental Sciences, 2017
Caprine milk CSN1S2 protein contains bioactive peptides that have a specific function in regulating the metabolic homeostasis mechanism between different organs. However, the safe dosage of goat milk consumption has not been established previously.
Fatchiyah Fatchiyah, Bambang Setiawan, Takeshi Ohta, Vita Agustina, Suharjono Suharjono   +4 more
doaj   +1 more source

Toxicity test of flavonoid compounds from the leaves of Dendrophthoe pentandra (L.) Miq. using in vitro culture cell models. [PDF]

Vet World, 2022
Lazuardi M, Suharjono S, Chien CH, He JL, Lee CW, Peng CK, Sukmanadi M, Sugihartuti R, Maslachah L.   +8 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

A Study on the Skin Irritation Toxicity Test of Processed Sulfur in New Zealand White Rabbit. [PDF]

J Pharmacopuncture, 2022
Jung H, Seo W, Jeong T, Kang HW, Kim S.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Utility of the avian sub-acute dietary toxicity test in ecological risk assessment and a path forward to reduce animal use. [PDF]

Integr Environ Assess Manag, 2022
Bone AJ, Brewer L, Habig C, Levine SL, Moore DRJ, Plautz S.   +5 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source