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Stevia rebaudiana extract (main components: chlorogenic acid and its analogues) as a new safe feed additive: evaluation of acute toxicity, sub chronic toxicity, genotoxicity, and teratogenicity [PDF]

Frontiers in Veterinary Science
IntroductionStevia rebaudiana extract (SREC), primarily composed of chlorogenic acid and its analogues, is a promising feed additive with potential benefits for livestock performance, gut health, and antioxidant capacity.
Yuting Li, Liping Zhu, Dongsheng He, Ling Fang, Yajing Li, Shusheng Tang   +5 more
doaj   +2 more sources

Safety Evaluation of the Aqueous Extract of the Mixture of Persea americana (Lauraceae), Cymbopogon citratus (Poaceae), Fruits of Citrus medica (Rutaceae), and Honey in Wistar Rat [PDF]

Journal of Toxicology
As part of the valorization of traditional medicine drugs, toxicological studies were carried out on the mixture of the aqueous extract of Persea americana, Cymbopogon citratus, Citrus medica, and honey, a traditional mixture recognized for its ...
Malane Nsangou Aicha El Ramadan, Bilanda Danielle Claude, Thamadeu Marie-Claire, Bidingha à Goufani Ronald, Tcheutchoua Yannick Carlos, Owona Pascal Emmanuel, Ngapout Fifen Rodrigue, Mbolang Nguegang Loick, Djientcheu Deugoue Franck Yvan, Dzeufiet Djomeni Paul Désiré, Kamtchouing Pierre   +10 more
doaj   +2 more sources

Subchronic Toxicity and Effect of the Methanolic Extract of Micromeria frivaldszkyana (Degen) Velen on Cognition in Male Wistar Rats [PDF]

Plants
Recently, compounds of plant origin have been the focus of increased scientific interest. Micromeria frivaldszkyana is a rare species endemic to Bulgaria, whose biological activity remains unknown. This article aims to evaluate the subchronic toxicity of
Elisaveta Apostolova, Kristina Stavrakeva, Vesela Kokova, Ivica Dimov, Mariya Choneva, Delyan Delev, Ilia Kostadinov, Iliya Bivolarski, Maria Koleva, Tsvetelina Mladenova, Krasimir Todorov, Anelia Bivolarska   +11 more
doaj   +2 more sources

A toxicological assessment of Hericium erinaceus (Lion’s mane) and Trametes versicolor (Turkey tail) mushroom powders [PDF]

Frontiers in Toxicology
Hericium erinaceus (Lion’s mane) and Trametes versicolor (Turkey Tail) mushrooms have an extensive history of use in traditional medicine and as food.
Kritika Mahadevan, Julie Daoust, Thomas Brendler, Thomas Brendler, Ankit Chaudhary, Alimuddin Saifi, Vipin Kumar Garg   +6 more
doaj   +2 more sources

Safety evaluation of extracellular vesicles derived from hypoxia primed mesenchymal stem cells of umbilical cord and adipose tissue [PDF]

Scientific Reports
Extracellular vesicles (EVs) hold great promise as regenerative therapeutics due to their roles in intercellular communication and tissue repair. This study aimed to assess the safety of EVs derived from human mesenchymal stem cells (MSCs) obtained from ...
Quyen Thi Nguyen, Nhung Thi Hong Dinh, Ngo Thu Hang, Can Van Mao, Xuan-Hai Do, Duc Son Le, Hong-Nhung Dao, T. Ngan Giang, Nicholas Forsyth, Van T. Hoang, Liem Nguyen Thanh   +10 more
doaj   +2 more sources

Evaluation of the safety and functional effects of recombinant humanized type III collagen in food toxicology [PDF]

Frontiers in Medicine
This study aimed to comprehensively assess the edible safety and in vivo bioactivities of recombinant humanized type III collagen (rhCol III). A systematic toxicological evaluation was conducted, including subchronic toxicity tests, bacterial reverse ...
Zhiyu Zhang, Wenqing Yang, Jingbo Yang, Xiaobin Lan, Chuanxiu Chen   +4 more
doaj   +2 more sources

Repeated Systemic Toxicity Tests: A Call for Proper Understanding of Tests Durations Nomenclature [PDF]

Asia Pacific Journal of Medical Toxicology, 2022
Background: Testing of substances such as drugs, food, cosmetics, and chemicals meant for human utilization requires necessary guidelines to be followed.
Earnest Erhirhie, Goodies Moke
doaj   +1 more source

Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: Piper crocatum Ruiz and Pav., Typhonium flagelliforme (Lodd.) Blume, and Phyllanthus niruri L. in Sprague–Dawley Rats

Journal of Toxicology, 2023
Background. The product combination of Piper crocatum Ruiz. and Pav., Phyllanthus niruri Linn., and Typhonium flagelliforme (Lodd.) BL ethanolic extract (SKM) exerts immunomodulatory activity.
Retno Murwanti, A. Nurrochmad, Andayana P. Gani, Ediati Sasmito, Angela E. Edwina, Mayang K. Chandra, F. H. Suryawan, A. R. Wardana, null Natalia, Jelita L. S. R. Budiningsih   +9 more
doaj   +1 more source

Evaluation of acute, subacute, and subchronic toxicity of a hepatoprotective herbal formulation

Toxicology Reports, 2023
Background: The possible toxicity of natural products must be tested before being used in the market. The present work aimed to evaluate acute, subacute, and subchronic toxicity of an herbal formulation containing Anethum graveolens, Cynara scolymus ...
Abolfazl Bemidinezhad, Seyyed Abbas Zojaji, Shirin Taraz Jamshidi, Mostafa Mohammadi, Mohaddeseh Sadat Alavi, Ahmad Ghorbani   +5 more
doaj   +1 more source

Acute and Subchronic Toxicity of Indonesian House Dust Mites (IHDM) Allergenic Extract for Asthma Allergy Immunotherapy

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2022
Background: In developing a pharmaceutical product, it is necessary to conduct pre-clinical and clinical trials to ensure its safety and effectiveness.
Aniek Setiya Budiatin, Yusuf Alif Pratama, Winda Fatma Sari, Mahardian Rahmadi, Muhammad Taher, Zainul Amiruddin Zakaria, Junaidi Khotib   +6 more
doaj   +1 more source