Results 11 to 20 of about 3,927 (153)

Toxicological evaluation of lactase derived from recombinant Pichia pastoris. [PDF]

PLoS ONE, 2014
A recombinant lactase was expressed in Pichia pastoris, resulting in enzymatic activity of 3600 U/mL in a 5 L fermenter. The lactase product was subjected to a series of toxicological tests to determine its safety for use as an enzyme preparation in the ...
Shiying Zou, Xiaoyun He, Yifei Liu, Delong Chen, Yunbo Luo, Kunlun Huang, Wei Zhang, Wentao Xu   +7 more
doaj   +1 more source

Optimization of Ethanol Extraction Technology for Yujin Powder Using Response Surface Methodology with a Box–Behnken Design Based on Analytic Hierarchy Process–Criteria Importance through Intercriteria Correlation Weight Analysis and Its Safety Evaluation

Molecules, 2023
Here, we aimed to optimize the ethanol extraction technology for Yujin powder (YJP) and evaluate its safety. The ultrasonic-assisted ethanol reflux extraction method refluxing was used to extract YJP.
Lidong Jiang, Wangdong Zhang, Wenbo Zhao, Yanzi Cai, Xue Qin, Baoshan Wang, Jiao Xue, Yanqiao Wen, Yanming Wei, Yongli Hua, Wanling Yao   +10 more
doaj   +1 more source

Subchronic Exposure to Aripiprazole Subtly Impacts on Rodents' Sperm Quality and Fertility. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Aripiprazole, a third‐generation antidepressant/antipsychotic drug, acts on serotonergic and dopaminergic receptors and is widely prescribed for mental disorders, such as depression and schizophrenia. Studies indicate that this class of drugs can impact directly on sperm quality and fertility.
de Moura MJN, de Felix RGS, da Silva AGG, Angelo ABS, Dos Santos CCA, Pereira AKH, de Macedo MF, Dos Borges CDS.   +7 more
europepmc   +2 more sources

A NEW FATHEAD MINNOW (PIMEPHALES PROMELAS) SUBCHRONIC TOXICITY TEST [PDF]

Environmental Toxicology and Chemistry, 1985
Abstract The most commonly used test for evaluating the toxicity of effluents to fish and invertebrates has been the acute lethality test. However, effluents frequently are not acutely toxic, and so assessing the sublethal effects on fish and invertebrates is important.
Teresa J. Norberg, Donald I. Mount
openaire   +1 more source

Edible Safety Assessment of Genetically Modified Rice T1C-1 for Sprague Dawley Rats through Horizontal Gene Transfer, Allergenicity and Intestinal Microbiota. [PDF]

PLoS ONE, 2016
In this study, assessment of the safety of transgenic rice T1C-1 expressing Cry1C was carried out by: (1) studying horizontal gene transfer (HGT) in Sprague Dawley rats fed transgenic rice for 90 d; (2) examining the effect of Cry1C protein in vitro on ...
Kai Zhao, Fangfang Ren, Fangting Han, Qiwen Liu, Guogan Wu, Yan Xu, Jian Zhang, Xiao Wu, Jinbin Wang, Peng Li, Wei Shi, Hong Zhu, Jianjun Lv, Xiao Zhao, Xueming Tang   +14 more
doaj   +1 more source

Hematological Parameters in Subchronic Toxicity Test of Black Garlic Ethanol Extract in Rats [PDF]

Journal of Fundamental and Applied Pharmaceutical Science, 2022
The community has used black garlic since ancient times for hypercholesterolemic. Until now, people still consume both raw and cooked black garlic. Black garlic is included in processed garlic products. People on the Asian continent have used black garlic for the past 10 years.
Ellen Stephanie Rumaseuw, Yoppi Iskandar, Eli Halimah   +2 more
openaire   +2 more sources

In vivo toxicity evaluation of a standardized extract of Syzygium aqueum leaf

Toxicology Reports, 2014
In this study, the acute and subchronic toxicity effect of the Syzygium aqueum leaf extract (SA) was evaluated. For the acute toxicity study, a single dose of 2000 mg/kg of the SA was given by oral-gavage to male Sprague-Dawley (SD) rats.
Thamilvaani Manaharan, Srikumar Chakravarthi, Ammu Kutty Radhakrishnan, Uma Devi Palanisamy   +3 more
doaj   +1 more source

Acute, subchronic toxicity and genotoxicity studies of JointAlive, a traditional Chinese medicine formulation for knee osteoarthritis.

PLoS ONE, 2023
AimIn vivo and in vitro toxicity tests of JointAlive® were studied in animal models to support the safe use of JointAlive® as a drug for knee osteoarthritis treatment.MethodsThe acute toxicity study in Sprague Dawley (SD) rats was conducted at a 20 g/kg ...
Yuanyuan Wang, Li Li, Yanling Mu, Shanglong Wang, Xin Li, Jiancheng Zong, Shengcan Zou, Zimin Liu, Dehai Gao   +8 more
doaj   +1 more source

Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer's disease mouse model.

PLoS ONE, 2021
Although numerous epidemiological studies revealed an association between ambient fine particulate matter (PM2.5) exposure and Alzheimer's disease (AD), the PM2.5-induced neuron toxicity and associated mechanisms were not fully elucidated.
Sheng-Han Lee, Yi-Hsuan Chen, Chu-Chun Chien, Yuan-Horng Yan, Hsin-Chang Chen, Hsiao-Chi Chuang, Hui-I Hsieh, Kuan-Hung Cho, Li-Wei Kuo, Charles C-K Chou, Ming-Jang Chiu, Boon Lead Tee, Ta-Fu Chen, Tsun-Jen Cheng   +13 more
doaj   +1 more source

Subacute and subchronic oral toxicity assessments of Acridocarpus smeathmannii (DC.) Guill. & Perr. root in Wistar rats

Toxicology Reports, 2019
Recent adverse herb reactions have stimulated interest documenting the safety profile of medicinal agents. Thus, subacute and subchronic oral toxicity of the hydroethanolic extract of Acridocarpus smeathmannii root (HEASR) in Wistar rats was investigated.
O.E. Kale, O. Awodele, A.J. Akindele
doaj   +1 more source