Results 21 to 30 of about 3,927 (153)

STUDY OF PHARMACOLOGICAL ACTIVITY OF NIGELLA DAMASCENA FIXED OIL IN EXPERIMENT [PDF]

Research Results in Pharmacology, 2017
Introduction: Literature data, rich chemical macro-microelement composition set the stage for experimental pharmacological study of adaptogene and lipid protective activity of Nigella damascena essential oil. Objectives: study of pharmacological activity
Marina Efremova, Aelita Ivasheva, Mikhail Korokin   +2 more
doaj   +3 more sources

An Evaluation of Oral Subchronic Toxicity of Maizinol (UP165), a Zea mays Leaf Extract. [PDF]

J Appl Toxicol
ABSTRACT Maize (Zea mays) has been consumed by humans for millennia and represents the third most abundant crop grown globally. Maize and maize‐derived products have a long history of safe consumption from bread and other cereal products in human diets worldwide. Aside from key dietary components like carbohydrates and proteins, the corn plant contains
Weston JK, Lynch BS, Akingbasote JA.
europepmc   +2 more sources

Toxicity Profiles of Kleeb Bua Daeng Formula, a Traditional Thai Medicine, and Its Protective Effects on Memory Impairment in Animals

Pharmaceuticals, 2022
Kleeb Bua Daeng (KBD) formula has long been used in Thailand as a traditional herbal medicine for promoting brain health. Our recent reports illustrated that KBD demonstrates multiple modes of action against several targets in the pathological cascade of
Pornthip Waiwut, Kanchana Kengkoom, Wanassanun Pannangrong, Natdanai Musigavong, Chantha Chheng, Kusawadee Plekratoke, Pitchayakarn Taklomthong, Nutchareeporn Nillert, Supaporn Pitiporn, Pakakrong Kwankhao, Supawadee Daodee, Yaowared Chulikhit, Orawan Montakantirat, Chantana Boonyarat   +13 more
doaj   +1 more source

Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

BMC Pharmacology and Toxicology, 2017
Background Cs2K4Na [SiW9Nb3O40] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other
Xiaofeng Qu, Kun Xu, Chao Zhao, Xiuling Song, Jinhua Li, Li Li, Wei Nie, Hao Bao, Juan Wang, Fenglan Niu, Juan Li   +10 more
doaj   +1 more source

Current Approaches to the Preclinical Assessment of Endocrine Toxicity

Безопасность и риск фармакотерапии, 2023
Scientific relevance. Endocrine disruptors affect the functioning of endocrine organs, which leads to adverse drug reactions. Endocrine toxicity requires special attention in preclinical studies of candidate medicinal products.Aim.
D. A. Babkov
doaj   +1 more source

Hepatotoxicity and subchronic toxicity tests of Morinda citrifolia (noni) fruit

The Journal of Toxicological Sciences, 2009
Morinda citrifolia (noni) fruit juice has been approved as a safe food in many nations. A few cases of hepatitis in people who had been drinking noni juice have been reported, even though no causal link could be established between the liver injury and ingestion of the juice.
Brett J, West, Chen X, Su, C Jarakae, Jensen   +2 more
openaire   +3 more sources

Toxicological Assessments of a Proprietary Blend of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies

Journal of Toxicology, 2022
LN18178 (Tesnor®) is a standardized, proprietary composition of aqueous ethanol extracts of Punica granatum fruit rind and Theobroma cacao seeds. The present study demonstrates a broad-spectrum toxicological evaluation of LN18178 utilizing in vitro and ...
Ravi Kumar Madireddy, Krishnaraju Venkata Alluri, Venkateswarlu Somepalli, Trimurtulu Golakoti, Krishanu Sengupta   +4 more
doaj   +1 more source

Safety Evaluation and Whole Genome Sequencing of Aspergillus japonicas PJ01 Reveal Its Potential to Degrade Citrus Segments in Juice Processing

Foods, 2021
Aspergillus japonicas PJ01 (A. japonicas PJ01) is a strain isolated from the rotten branches. In previ-ous studies, it was shown that it can produce complex enzymes to degrade polysaccharide com-ponents.
Yujiao Qian, Zhipeng Gao, Jieyi Wang, Chen Wang, Gaoyang Li, Fuhua Fu, Jiajing Guo, Yang Shan   +7 more
doaj   +1 more source

Safety and efficacy profile of a phytase produced by fermentation and used as a feed additive

Heliyon, 2021
Enzymes can aid in optimal feed stock utilization when used as feed additives. A range of toxicological studies were performed to evaluate the safety profile of a novel phytase (phytase HM) from Citrobacter braakii produced in Aspergillus oryzae. Phytase
Michael Thorsen, Line Anker Nielsen, Heng-Xiao Zhai, Qian Zhang, Linda Wulf-Andersen, Lars Kobberøe Skov   +5 more
doaj   +1 more source

Safety evaluation of ethanol extract from Artocarpus altilis leaves as a herbal medicine candidate: Studies in acute and subchronic toxicity

Phytomedicine Plus
Background: Artocarpus altilis is a traditional medicine proven to be efficacious in several pharmacological tests using animal models. However, there have been no reports regarding its safety so far.
Fitrya Fitrya, Elfita Elfita, Ferlinahayati, Salma Fayzah Septami, Umi Tsalsa Sabrina, Fatma Sri Wahyuni, Annisa Amriani, Rennie Puspa Novita   +7 more
doaj   +1 more source