Results 91 to 100 of about 18,256 (198)

Kinetic Considerations in the Interpretation of Biomonitoring of 1,3-Butadiene Exposure by Determination of Urinary Mercapturic Acids

Toxics
1,3-Butadiene (BD) is classified as a human carcinogen, and occupational exposure should be minimized. This study examined the effectiveness of personal protective equipment (PPE) during the clean-up and repair of a storage tank containing sludge ...
Peter J. Boogaard, Mary Freire de Carvalho, Maryam Zare Jeddi   +2 more
doaj   +1 more source

Physiological modes of action across species and toxicants : the key to predictive ecotoxicology [PDF]

, 2017
As ecotoxicologists we strive for a better understanding of how chemicals affect our environment. Humanity needs tools to identify those combinations of man-made chemicals and organisms most likely to cause problems. In other words: which of the millions
Agatz, Alda Álvarez, Alda ÁLvarez, Alda Álvarez, Ankley, Ashauer, Augustine, Barsi, Bhattacharya, Billoir, Billoir, Boyd, Bánszegi, Cedergreen, De Laender, Escher, Forbes, Goussen, Groh, Gunawardena, Gunnarsson, Heckmann, Hendriks, Hines, Huang, Jager, Jager, Jager, Jager, Jager, Jager, Jager, Jager, Jager, Jager, Jager, Jager, Jager, Jager, Jung, Kienzler, Klok, Klok, Kooijman, LaLone, Laskowski, Li, Mallard, Margerit, Martin, Martin, Massarin, Muller, Muller, Muller, Nisbet, Pieters, Relyea, Rohr, Rubach, SCENIHR (Scientific Committee on Emerging and Newly Identified Health Risks), Schäfer, Sousa, Stadnicka-Michalak, Stehle, Swain, Van den Brink, Villeneuve, Watanabe, Wittwehr, Wren, Zhang   +71 more
core   +1 more source

The characteristics and prognostic factors on initial presentation to healthcare facilities associated with poor outcomes in acute or acute‐on‐chronic digoxin poisoning in Hong Kong

Hong Kong Journal of Emergency Medicine, Volume 33, Issue 2, April 2026.
Abstract Background Digoxin is a commonly used cardiovascular drug but has a narrow therapeutic window, and its poisoning could be fatal. Prognostic factors of digoxin poisoning were proposed largely based on the toxicokinetics of digoxin. Higher levels of evidence on this topic were limited.
Pui Hang Belle Lau, Yuet Yee Wu, Shing Kit Tommy Lam, Tin Yat Anthony Chow, Ping Wu, Oi Fung Wong, Chi Keung Chan, Man Li Tse   +7 more
wiley   +1 more source

Pesticide prioritization based on risk and model diet proposals for assessing cumulative exposure to pesticide residues in the Brazilian population through food consumption

Pest Management Science, Volume 82, Issue 4, Page 3853-3873, April 2026.
A risk classification of registered pesticides in Brazil was conducted, and the contribution of food to cumulative pesticide exposure was evaluated. Model diets were proposed, based on Brazilian consumption patterns. Abstract BACKGROUND Pesticide residue exposure assessments can be carried out during both the pre‐regulation and post‐regulation phases ...
Bianca Figueiredo de Mendonça Pereira, Bernardete Ferraz Spisso   +1 more
wiley   +1 more source

Granica sigurnosti za intravaskularna kontrastna sredstva: tjelesna težina, površina ili toksikokinetički pristup? [PDF]

, 2005
The margin of safety of a drug is defined as the ratio between toxicity in animals and safety in humans. For intravascular contrast media, the margin of safety is traditionally the ratio between LD50 and diagnostic dose, both doses being based on ...
Alberto Morisetti, Simona Bussi
core   +1 more source

Toxicokinetics of Ag in the terrestrial isopod Porcellionides pruinosus exposed to Ag NPs and AgNO3 via soil and food [PDF]

, 2015
Silver nanoparticles (Ag NPs) have been used in numerous consumer products and may enter the soil through the land application of biosolids. However, little is known about the relationship between Ag NP exposure and their bioavailability for soil ...
Jurkschat, Kerstin, Kille, Peter, Loureiro, Susana, Morgan, A. John, Mosselmans, J. Fred W., Soares, Amadeu M.V.M., Svendsen, Claus, Tourinho, Paula S., van Gestel, Cornelis A.M.   +8 more
core   +1 more source

Aluminium Toxicokinetics [PDF]

Pharmacology & Toxicology, 1990
M, Wilhelm, D E, Jäger, F K, Ohnesorge
openaire   +2 more sources

Integration of Machine Learning With PBPK and QSAR Modeling Approaches to Facilitate Drug Discovery and Development

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 4, April 2026.
ABSTRACT This review examines the application of machine learning (ML) in physiologically based pharmacokinetic (PBPK) modeling through improved prediction of input parameters, particularly via quantitative structure–activity relationship (QSAR) models, for absorption, distribution, metabolism, and excretion (ADME) properties across drug development ...
Xinyue Chen, Zhoumeng Lin
wiley   +1 more source

Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research. [PDF]

, 2019
BackgroundThe National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use.
(Environmental influences on Child Health Outcomes), Beamer, Paloma I, Bennett, Deborah H, Boyles, Rebecca R, Buckley, Jessie P, Kannan, Kurunthachalam, Pellizzari, Edo D, Wang, Aolin, Woodruff, Tracey J, Zhu, Yeyi   +9 more
core  

ECVAM Technical Report on the Status of Alternative Methods for Cosmetics Testing (2008-2009) [PDF]

, 2010
The ECVAM technical report presents the progress made in the development and validation of alternative methods for the human health effects relevant to the Cosmetics Directive. It provides an update on the activities described by ECVAM in 2005 , 2006 and
BREMER Susanne, CASATI Silvia, CERIDONO MARA, COECKE Sandra, CORVI Raffaella, ESKES Chantra, KINSNER-OVASKAINEN Agnieszka, KREYSA JOACHIM, PELLIZZER Cristian, PRIETO PERAITA Maria Del Pilar, VIEGAS BARROSO JOAO FILIPE, WORTH Andrew, ZUANG Valerie   +12 more
core   +1 more source