Results 31 to 40 of about 9,004 (219)

Refinement of the acute inhalation limit test for inert, nano-sized dusts by an in silico dosimetry-based evaluation: case study for the dissolution of a regulatory dilemma

Frontiers in Toxicology, 2023
This case study aims to describe the dilemma faced when exposing rats to very high concentrations of fine, pulverulent materials for acute inhalation studies and to address the regulatory question of whether the effects seen here are relevant to humans ...
Heidi Stratmann, Lan Ma-Hock, Simone Tangermann, Richard A. Corley   +3 more
doaj   +1 more source

Toxicokinetics of lambda-cyhalothrin in rats

, 2006
The toxicokinetics of lambda-cyhalothrin after single 20 mg kg(-1) oral and 3 mg kg(-1) intravenous doses were studied in rats. Serial blood samples were obtained after oral and intravenous administration.
Martínez Caballero, Marta, Martínez Caballero, María Aranzazu, Diaz, Manuel Jesús, Anadón Navarro, Arturo Ramón, Martínez Larrañaga, María Rosa   +4 more
core   +1 more source

Toxicokinetics of copper and cadmium in the soil model Enchytraeus crypticus (Oligochaeta) [PDF]

, 2021
Toxicokinetics information is key to understanding the underlying intoxication processes, although this is often lacking. Hence, in the present study the toxicokinetics of copper (Cu) and cadmium (Cd) was assessed in the soil invertebrate Enchytraeus ...
Amorim, Mónica J.B., van Gestel, Cornelis A.M.; id_orcid, van Gestel, Cornelis A.M., Santos, Fátima C.F.   +3 more
core   +1 more source

Study of the Safety and Toxicokinetic Parameters of the Drug Eladis® in Preclinical Trials with Repeated Administration

Антибиотики и Химиотерапия
Cough is one of the most common reasons for initial visits to healthcare providers, affecting 40–50% of patients with viral respiratory tract infections.
A. A. Matichin, M. V. Miroshnikov, A. A. Matichina, V. M. Kosman, M. V. Karlina, E. M. Petrova, A. A. Globenko, E. A. Jain, A. V. Kapashin, A. L. Vladykin, A. S. Kolosov, M. A. Pasko   +11 more
doaj   +1 more source

Benzene, toluene, ethylbenzene, and xylene: Current analytical techniques and approaches for biological monitoring

Reviews in Analytical Chemistry, 2020
Benzene, toluene, ethylbenzene, and xylene (BTEX) are a group of volatile organic compounds that human exposure to them may result in the development of some diseases, including cancer. Biological monitoring plays an important role in exposure assessment
Soleimani Esmaeel
doaj   +1 more source

Calcination Improves the In Vivo Efficacy of a Montmorillonite Clay to Bind Aflatoxin G1 in Broiler Chickens: A Toxicokinetic Approach

Toxins, 2020
The goal of this study was to investigate the toxicokinetic characteristics of aflatoxin G1 (AFG1) in broiler chickens and the effect of calcination of a Tunisian montmorillonite clay on the in vivo absorption of AFG1.
Roua Rejeb, Siegrid De Baere, Mathias Devreese, Richard Ducatelle, Siska Croubels, Madiha Hadj Ayed, Achraf Ghorbal, Gunther Antonissen   +7 more
doaj   +1 more source

Decoding Tattoo and Permanent Makeup Pigments: Linking Physicochemical Properties to Absorption, Distribution, Metabolism, and Elimination Profiles Using Quantitative Structure–Activity Relationship (QSAR)‐Based New Approach Methodologies (NAMs)

Advanced Intelligent Discovery, EarlyView.
This study applies QSAR‐based new approach methodologies to 90 synthetic tattoo and permanent makeup pigments, revealing systemic links between their physicochemical properties and absorption, distribution, metabolism, and elimination profiles. The correlation‐driven analysis using SwissADME, ChemBCPP, and principal component analysis uncovers insights
Girija Bansod, Ajay Vikram Singh, Preeti Bhardwaj, Tulika Rai, Sweta Vijay Nakhale, Amruta Shelar, Rajendra Patil, Peter Laux, Andreas Luch, Christopher J. Osgood, Michael W. Stacey   +10 more
wiley   +1 more source

Aluminium Toxicokinetics: An Updated MiniReview

, 2001
This MiniReview updates and expands the MiniReview of aluminium toxicokinetics by Wilhelm et al. published by this journal in 1990. The use of 26Al, analyzed by accelerator mass spectrometry, now enables determination of Al toxicokinetics under ...
Yokel, Robert A., McNamara, Patrick J.
core   +1 more source

Preclinical Evaluation of Esomeprazole Safety and Toxicokinetics

, 2023
Esomeprazole, the S-isomer of omeprazole, is a second-generation proton pump inhibitor widely used for acid-related diseases of the oesophagus, stomach, and duodenum (peptic ulcer, gastro-oesophageal reflux disease, etc.).
A. A. Globenko, V. G. Makarov, E. V. Mazukina, V. M. Kosman, M. V. Karlina, M. N. Makarova, E. A. Jain   +6 more
core   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source