Results 41 to 50 of about 9,004 (219)
Effect of Gene-Mercury Interactions on Mercury Toxicokinetics and Neurotoxicity
, 2015 Individuals differ in susceptibility to mercury neurotoxicity, in part, due to underlying genetic differences. This review aims to evaluate the state-of-the-art of the effect of (1) genetics on mercury toxicokinetics and (2) gene-mercury interactions on ...
Ballester, F, Llop, S, Broberg, K
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Temperature-Dependent Toxicokinetics of Phenanthrene in Enchytraeus albidus (Oligochaeta) [PDF]
, 2021 Although the toxicokinetics of organic pollutants in soil invertebrates under optimal and constant temperature has been widely reported, their uptake, elimination, and bioaccumulation under suboptimal temperatures, and especially daily fluctuating ...
Dai, Wencai +4 more
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, 2014 Citation: 'toxicokinetics' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.T06416 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
A Roberts, Andrew Renwick
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Toxicologie industrielle et vieillissement
Perspectives Interdisciplinaires sur le Travail et la Santé, 2004 Several physiological and biochemical changes accompany aging and can affect the metabolism of chemicals and the body’s response. A literature review was carried out to identify these changes and their potential impact on the health of aging workers. The
Ginette Truchon +2 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims In the context of pharmacology and toxicology education, there is a growing shift toward programmatic assessment models that prioritize longitudinal learning, reflection and development of higher‐order cognitive skills. As part of this transition, we are exploring alternative and more meaningful forms of assessment. This qualitative study
Narin Akrawi +2 more
wiley +1 more source
High-Throughput Toxicokinetics Data
, 2018 It is important to link the external dose of a chemical to an internal blood or tissue concentration; this process is called toxicokinetics. EPA researchers measure the critical factors that determine the distribution and metabolic clearance for hundreds
EPA's National Center for Computational Toxicology (5039467)
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British Journal of Clinical Pharmacology, EarlyView.Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg +7 more
wiley +1 more source
Female Sex Hormones Alter GHB Toxicokinetics
, 2022 Gamma-Hydroxybutyrate (GHB) is an endogenous short-chain fatty acid formed from gamma-aminobutyric acid (GABA). Clinically, GHB is marketed in the United States as Xyrem to treat narcolepsy with cataplexy and in Europe for the treatment of alcohol ...
Nicholson, Tori +3 more
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Current Issues in Molecular BiologyDue to continuous application as a flavoring agent in the pesticide, pharmaceutical, and food industries, methyl eugenol (ME) persists in the environment and causes deleterious impacts including cytotoxicity, genotoxicity, and liver damage.
Liang Chen +3 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh +5 more
wiley +1 more source