Results 21 to 30 of about 9,004 (219)

Chronic Exposure to Deoxynivalenol Has No Influence on the Oral Bioavailability of Fumonisin B1 in Broiler Chickens

Toxins, 2015
Both deoxynivalenol (DON) and fumonisin B1 (FB1) are common contaminants of feed. Fumonisins (FBs) in general have a very limited oral bioavailability in healthy animals.
Gunther Antonissen, Mathias Devreese, Filip Van Immerseel, Siegrid De Baere, Sabine Hessenberger, An Martel, Siska Croubels   +6 more
doaj   +1 more source

Emerging Fusarium and Alternaria Mycotoxins: Occurrence, Toxicity and Toxicokinetics

Toxins, 2017
Emerging Fusarium and Alternaria mycotoxins gain more and more interest due to their frequent contamination of food and feed, although in vivo toxicity and toxicokinetic data are limited.
Sophie Fraeyman, Siska Croubels, Mathias Devreese, Gunther Antonissen   +3 more
doaj   +1 more source

Toxicokinetics of β-Amanitin in Mice and In Vitro Drug–Drug Interaction Potential

Pharmaceutics, 2022
The toxicokinetics of β-amanitin, a toxic bicyclic octapeptide present abundantly in Amanitaceae mushrooms, was evaluated in mice after intravenous (iv) and oral administration.
Young Yoon Bang, Im-Sook Song, Min Seo Lee, Chang Ho Lim, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Hye Suk Lee   +7 more
doaj   +1 more source

Metabolism and in vitro assessment of the mutagenic activity of urinary extracts from rats after inhalation exposure to 1-methylnaphthalene

International Journal of Occupational Medicine and Environmental Health, 2022
Objectives 1-Methylnaphthalene (1-MN) is composed of 2 benzene rings and belongs to polycyclic aromatic hydrocarbons. The metabolism of 1-MN in laboratory animals and bacteria leads to the formation of 1-naphthoic acid (1-NA).
Radosław Świercz, Maciej Stępnik, Jolanta Gromadzińska, Katarzyna Domeradzka-Gajda, Joanna Roszak, Wojciech Wąsowicz   +5 more
doaj   +1 more source

Toxicity Study of 28-Day Subcutaneous Injection of Arctigenin in Beagle Dogs

Frontiers in Pharmacology, 2019
Our previous studies have investigated the systematic pharmacokinetic characteristics, biological activities, and toxicity of arctigenin. In this research, the potential toxicities of arctigenin in beagle dogs were investigated via repeated 28-day ...
Jie Li, Jie Li, Jie Li, Yun-gang Lv, Li-hong Pan, Li-hong Pan, Li-hong Pan, Fang-fang Yao, Fang-fang Yao, Tao Peng, Tao Peng, Tao Peng, Yu-jun Tan, Yu-jun Tan, Yu-jun Tan, Gui-Min Zhang, Gui-Min Zhang, Gui-Min Zhang, Gui-Min Zhang, Zhong Liu, Zhong Liu, Zhong Liu, Zhong Liu, Jing-chun Yao, Jing-chun Yao, Jing-chun Yao, Yu-shan Ren, Yu-shan Ren, Yu-shan Ren   +28 more
doaj   +1 more source

Toxicokinetics and bioaccumulation of silver sulfide nanoparticles in benthic invertebrates in an indoor stream mesocosm [PDF]

, 2023
Mesocosms allow the simulation of environmentally relevant conditions and can be used to establish more realistic scenarios of organism exposure to nanoparticles.
Ferreira, Abel, Silva, Ana Rita R., Handy, Richard, Patrícia V. Silva, Victor Puntes, Silva, ARR, Lynch, Iseult; id_orcid, Gestel, Cornelis A. M. van, Nathaniel J. Clark, van den Brink, Nico W., Iseult Lynch, Puntes, Víctor F., Jurkschat, Kerstin, Nico W. van den Brink, Lynch, Iseult, Handy, Richard D., Papadiamantis, Anastasios G., van Gestel, Cornelis A.M.; id_orcid, Baccaro, Marta, Clark, Nathaniel J, van, Gestel CAM, Silva, PV, van, den Brink NW, Cornelis A.M. van Gestel, Svendsen, Claus, Richard D. Handy, Papadiamantis, Anastasios G, Silva, Patrícia V, Susana Loureiro, Claus Svendsen, Medvešček, Neja, Magdalena Grgić, Vassallo, Joanne, Clark, Nathaniel, van den Brink, Nico W, Handy, Richard D, Ana Rita R. Silva, Abel Ferreira, Busquets-Fité, Martí, Kerstin Jurkschat, Silva, Patrícia V., van Gestel, Cornelis A M, Puntes, Victor, Marta Baccaro, Anastasios G. Papadiamantis, Brink, Nico W. van den, Joanne Vassallo, Neja Medvešček, van Gestel, Cornelis A.M., Grgić, Magdalena, Loureiro, Susana, Martí Busquets-Fité, Clark, Nathaniel J., Silva, Ana Rita R   +53 more
core   +1 more source

Statement of EFSA on the Evaluation of a new study related to the bioavailability of aluminium in food

EFSA Journal, 2011
The European Food Safety Authority (EFSA) was asked to evaluate a new study provided by industry that reports on the bioavailability of aluminium from several aluminium compounds in the rat.
European Food Safety Authority
doaj   +1 more source

Uptake, Elimination and Metabolism of Brominated Dibenzofurans in Mice

Toxics
Polybrominated dibenzofurans (PBDFs) are major brominated dioxins in the environment, but information on their bioaccumulation potential and toxicokinetics is limited.
Nguyen Minh Tue, Eiki Kimura, Fumihiko Maekawa, Akitoshi Goto, Naoto Uramaru, Tatsuya Kunisue, Go Suzuki   +6 more
doaj   +1 more source

Transition to the Non-Clinical Drug Development Principles and Rules of the Eurasian Economic Union: Changes, Challenges, and Prospects

Безопасность и риск фармакотерапии, 2023
It is strategically critical to secure pharmaceutical independence for Russia by developing the industry using the latest achievements in science and technology.
A. A. Spasov
doaj   +1 more source

Genetic polymorphism and pharmacokinetics/toxicokinetics of carbamazepine: A general review [PDF]

Vojnosanitetski Pregled
Carbamazepine (CBZ) is a widely used medication in treating epilepsy, bipolar disorder, and neuropathic pain. Its pharmacokinetic profile is highly variable due to slow absorption, extensive metabolism, and auto-induction.
Kovačević Aleksandra, Lukić Vladan, Cikota-Aleksić Bojana, Janković Slobodan M., Dragojević-Simić Viktorija   +4 more
doaj   +1 more source