Results 1 to 10 of about 9,004 (219)
The In Vivo and In Vitro Toxicokinetics of Citreoviridin Extracted from Penicillium citreonigrum
Toxins, 2019 Citreoviridin (CTVD), a mycotoxin called yellow rice toxin, is reported to be related to acute cardiac beriberi; however, its toxicokinetics remain unclear.
Yosuke Uchiyama +5 more
doaj +2 more sources
Advances in Pharmacological Sciences, 2011 Kava is traditionally consumed by South Pacific islanders as a drink and became popular in Western society as a supplement for anxiety and insomnia. Kava extracts are generally well tolerated, but reports of hepatotoxicity necessitated an international ...
Anthony Rowe +2 more
doaj +3 more sources
PharmaceuticsΓ-hydroxybutyric acid (GHB) is widely abused due to its sedative/hypnotic and euphoric effects. In recent years, GHB use has witnessed a notable rise within the LGBTQ+ community.
Qing Zhang +3 more
doaj +2 more sources
Comparative Toxicokinetics and Biomarker Responses of Typical Psychiatric Pharmaceuticals in Daphnia magna [PDF]
ToxicsThe widespread availability and pseudo-persistence of typical psychiatric pharmaceuticals (PDs) can have serious impacts on aquatic ecosystems and even human health.
Haohan Yang +5 more
doaj +2 more sources
Toxicokinetics in Risk Evaluations [PDF]
Chemical Research in Toxicology, 2018 Quantitative predictions of in vivo chemical levels based on in vitro data will become a cornerstone of next generation nonanimal risk evaluations. Both regulatory and scientific experience with quantitative toxicokinetics must increase now for this transition to happen.
Punt, Ans
openaire +3 more sources
Toxicokinetics of a Single Oral Dose of Aflatoxin B1 in Plasma, Feces, and Urine of Male Donkeys [PDF]
ToxinsAflatoxin B1 (AFB1) is widely present in raw materials for food and feedstock, posing a significant threat to the health of humans and animals. This study explored the toxicokinetics of a single oral administration of AFB1 at a dose of 100 µg·kg−1 BW ...
Yulong Feng +9 more
doaj +2 more sources
Enterohepatic Recirculation-Mediated Reabsorption of Aristolochic Acid I: Revealed by Toxicokinetics and Metabolite Identification in Rats [PDF]
ToxicsAristolochic acid I (AAI) is widely recognized as a genotoxic and cytotoxic compound. To rationally propose detoxification strategies, it is essential to fully elucidate the in vivo disposition of AAI.
Lieyan Huang +5 more
doaj +2 more sources
Derivation of Human Toxicokinetic Parameters and Chemical-Specific Adjustment Factor of Citrinin Through a Human Intervention Trial and Hierarchical Bayesian Population Modeling [PDF]
ToxinsBackground: Citrinin (CIT) is a mycotoxin produced by various fungi contaminating stored cereals and fruits. While biomonitoring and food occurrence data indicate widespread exposure, its public health risks remain unclear due to the lack of human ...
Lia Visintin +5 more
doaj +2 more sources
Journal of Nanobiotechnology, 2021 The widespread use of nanomaterials (NMs) has raised concerns that exposure to them may introduce potential risks to the human body and environment. The liver is the main target organ for NMs.
Ting Sun +7 more
doaj +1 more source
Frontiers in Toxicology, 2022 Physiologically based kinetic (PBK) modeling has been increasingly used since the beginning of the 21st century to support dose selection to be used in preclinical and clinical safety studies in the pharmaceutical sector.
Engi Abdelhady Algharably +6 more
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