Results 11 to 20 of about 9,004 (219)

Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support

Frontiers in Pediatrics, 2021
Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal.
Maria Pérez Marín, Sylvain Prod'hom, Suzanne Francesca de Villiers, Thomas Ferry, Vivianne Amiet, Julia Natterer, Maria-Helena Perez, Thierry Buclin, Haithem Chtioui, David Longchamp   +9 more
doaj   +1 more source

Species Sensitivity to Toxic Substances: Evolution, Ecology and Applications

Frontiers in Environmental Science, 2020
Because it is only possible to test chemicals for effects on a restricted range of species and exposure scenarios, ecotoxicologists are faced with a significant challenge of how to translate the measurements in model species into predictions of impacts ...
David Spurgeon, Elma Lahive, Alex Robinson, Stephen Short, Peter Kille   +4 more
doaj   +1 more source

Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for 3 months

Frontiers in Pharmacology, 2023
Introduction: Recombinant human fibroblast growth factor 21 (FGF-21) is a potential therapeutic agent for multiple metabolic diseases. However, little is known about the toxicokinetic characteristics of FGF-21.Methods: In the present study, we ...
Chao Lu, Chao Lu, Chao Lu, Lei Jin, Lei Jin, Jianing Bi, Hongyi Jin, Xinyi You, Lulu Peng, Haibing Fan, Huan Wang, Liangshun Wang, Zhengkai Fan, Xiaojie Wang, Xiaojie Wang, Xiaojie Wang, Baohua Liu, Baohua Liu   +17 more
doaj   +1 more source

The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin

Physiological Reports, 2022
The most widely used formalin test to screen antinociceptive drug candidates is still apostrophized as targeting inflammatory pain, in spite of strong opposing evidence published.
Tal Hoffmann, Florian Klemm, Tatjana I Kichko, Susanne K Sauer, Katrin Kistner, Bernhard Riedl, Patrick Raboisson, Lei Luo, Alexandru Babes, Laurence Kocher, Giancarlo Carli, Michael J. M. Fischer, Peter W. Reeh   +12 more
doaj   +1 more source

A Computational Understanding of Inter-Individual Variability in CYP2D6 Activity to Investigate the Impact of Missense Mutations on Ochratoxin A Metabolism

Toxins, 2022
Cytochrome P-450 (CYP) enzymes have a key role in the metabolism of xenobiotics of food origin, and their highly polymorphic nature concurs with the diverse inter-individual variability in the toxicokinetics (TK) and toxicodynamics (TD) of food chemicals.
Jean Lou C. M. Dorne, Martina Cirlini, Jochem Louisse, Lorenzo Pedroni, Gianni Galaverna, Luca Dellafiora   +5 more
doaj   +1 more source

The toxicokinetic profile of Dex40-GTMAC3 - a novel polysaccharide candidate for reversal of unfractionated heparin.

Frontiers in Pharmacology, 2016
Though protamine sulfate is the only approved antidote of unfractionated heparin (UFH), yet may produce life threatening side effects such as systemic hypotension, catastrophic pulmonary vasoconstriction or allergic reactions.
Emilia eSokolowska, Bartlomiej eKalaska, Kamil eKaminski, Alicja eLewandowska, Agnieszka eBlazejczyk, Joanna eWietrzyk, Irena eKasacka, Krzysztof eSzczubialka, Dariusz ePawlak, Maria eNowakowska, Andrzej eMogielnicki   +10 more
doaj   +1 more source

Toxicokinetics of a humanized anti-cocaine monoclonal antibody in male and female rats and lack of cross-reactivity

Human Vaccines & Immunotherapeutics, 2023
A humanized monoclonal antibody h2E2 designed to bind cocaine with high affinity, specificity, and a long half-life (~7 d in rats) is being developed as a treatment for cocaine use disorder.
Rose P. Webster, Jordan A. Marckel, Andrew B. Norman   +2 more
doaj   +1 more source

Rapid Domoic Acid Depuration in the Scallop Argopecten purpuratus and Its Transfer from the Digestive Gland to Other Organs

Toxins, 2020
Domoic acid (DA), the main toxin responsible for Amnesic Shellfish Poisoning, frequently affects the marine resources of Chile and other countries across the South Pacific, thus becoming a risk for human health.
Gonzalo Álvarez, José Rengel, Michael Araya, Francisco Álvarez, Roberto Pino, Eduardo Uribe, Patricio A. Díaz, Araceli E. Rossignoli, Américo López-Rivera, Juan Blanco   +9 more
doaj   +1 more source

Emerging investigator series:perspectives on toxicokinetics of nanoscale plastic debris in organisms

, 2022
Fragmentation of plastic waste in the environment can lead to the formation of nanoscale plastic debris (NPD) of size < 1 μm. Although it is reported that NPD can be taken up by organisms, the current lack of knowledge regarding its toxicokinetics is ...
Fazel Abdolahpur Monikh, Raine Kortet, Kortet, Raine, Martina G. Vijver, Peijnenburg, W.J.G.M., Lynch, Iseult; id_orcid, Abdolahpur Monikh, F., Vijver, M.G., Iseult Lynch, Willie J. G. M. Peijnenburg, Monikh, Fazel Abdolahpur, Vijver, Martina G., Lynch, I., Kortet, R., Peijnenburg, Willie J. G. M.   +14 more
core   +1 more source

Category-Based Toxicokinetic Evaluations of Data-Poor Per- and Polyfluoroalkyl Substances (PFAS) using Gas Chromatography Coupled with Mass Spectrometry

Toxics, 2023
Concern over per- and polyfluoroalkyl substances (PFAS) has increased as more is learned about their environmental presence, persistence, and bioaccumulative potential.
Anna Kreutz, Matthew S. Clifton, W. Matthew Henderson, Marci G. Smeltz, Matthew Phillips, John F. Wambaugh, Barbara A. Wetmore   +6 more
doaj   +1 more source